Octinoxate

Drug ingredient

CAS 5466-77-3

Companies reported imports and no US production of this drug ingredient to EPA for 2023.

Molecular structure of 5466-77-3
US productionZero
Import value, 2024$370M
Import volume8.3M lb
Import dependency100%
Top sourceIndia 45%

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Octinoxate · US import value by year
$335M2013$621M2022$370M2024$400M2025

2013: $335M · Peak 2022: $621M · 2024: $370M · 2025: $400M

Where It Comes From

Customs basis: HS 291899 · basket

EPA reports by year
2023
US production Zero · Imports 8.3M lb
2019
US production Confidential · Imports Confidential

These shares come from HS customs code 291899, which covers 139 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IN 45%IndiaCN 35%ChinaGB 7%United KingdomCO 3%ColombiaCH 3%Switzerland
Domestic parents -- activity not disclosed (1)
Reckitt Benckiser
EPA-registered importers (2)
Reckitt Benckiser Group · GB United Kingdom
Givaudan Fragrances
279 FDA-registered drug labelers
21st Century Formulations
3LAB, Inc
ABBE Laboratories, Inc.
Able C&C Co., Ltd.
Access Business Group LLC
Aekyung Industrial Co., Ltd.
Allergan, Inc.
Allure Labs, LLC
Aloe Care International, LLC
ALTONA COSMETICS TECHNOLOGY SANAYI VE TICARET ANONIM SIRKETI
AMCOL Health & Beauty Solutions, Inc. DBA
Amish Origins
AMOREPACIFIC CORPORATION
Amway Corp
Andalou naturals
Anna Lotan Ltd
Anthony Skin LLC
ANUBIS COSMETICS SL
Anything SPF LLC
ARUBA ALOE BALM NV
ATAK FARMA KOZMETIK VE KIMYA SANAYI TICARET ANONIM SIRKETI
Australian Gold
Bali Body Pty Ltd
Balshi MD Dermaceuticals
BAMKO, LLC
BASF Corporation
BASF SE
Bausch & Lomb Incorporated
Baxter Laboratories Pty. Ltd.
BAY BELLE LABS
BCM Cosmetique SAS
BCMC
Beiersdorf Inc
BEL STAR S A
Bel Star S.A. (Colombia)
Bentley Laboratories LLC
Bio-Medical & Pharmaceutical Manufacturing Corporation
Biocosmetica Exel Argentina SRL
Biodermis, LLC
Bioelements
Bioelements, Inc
Bitchistix, LLC
Bitchstix, LLC
Blistex Inc
Bluemercury
BLUEZONWIDE CO.,LTD
Bobbi Brown Professional Cosmetics Inc.
Boscia LLC
Botanical Science Technologies
BOTANICAL SCIENCE, INC.
BPS 60
Brownkind Dermascience Inc.
Bu Brands, LLC
BULLFROG BRANDS, LLC.
BURND LLC
C.F.E.B. Sisley
CALLIEL PHARMA KOZMETIK SANAYI VE TICARET ANONIM SIRKETI
Carma Laboratories, Inc.
Casad Company Inc.
Chantecaille Beaute Inc
Charlotte Tilbury Beauty Ltd.
Chemspec Chemicals PVT LTD
CHIPICAN LLC
Circadia by Dr Pugliese, Inc.
CLINIQUE LABORATORIES LLC
Columbia Cosmetics Manufacturing, Inc.
Conopco d/b/a/ Unilever
CONOPCO Inc. d/b/a Unilever
CONTROL CORRECTIVE SKINCARE INC
CoreTex Products Inc
COSMAX USA, CORPORATION
COSMAX USA, INC
Cosmed Dermaceuticals, Inc.
Cosmetic Enterprises Ltd
CP Skin Health Group, Inc
CP Skin Health, Inc
CVS
CVS Health
CVS Pharmacy, Inc
Dermaesthetics Inc.
Dermatone
Dermazone LLC
DermStore, LLC
Diractions Capital LLC
Distribuidora Comercial Jafra, S.A. de C.V.
DONGDONGGURIMOO CO.,LTD.
Dongguan Taimeng Accessories Co., Ltd.
Dr Pawpaw Limited
Dr. Natural LLC
Drmtlgy, LLC
DSM Nutritional Products, LLC
DUKE CANNON SUPPLY CO.
Durvet, Inc.
Dynarex
Earth's Daughter
Eco Lips. Inc.
ELEMIS Limited
Elysium Consumer Healthcare LLC
Eminence Organic Skin Care
Emma Hardie Ltd
Epicuren Discovery
Epicuren Disocovery
ERKUL KOZMETIK SANAYI VE TICARET ANONIM SIRKETI
Erno Laszlo, Inc.
ESTEE LAUDER INC
EVI LABS
Exelencia importers
Exelencia Importers, Corp.
Extra Shade, LLC
FARMASI US LLC
Flageoli Limited
fmg Co.Ltd
Focus Consumer Healthcare, LLC
Foshan Miwei Cosmetics Co., Ltd.
Fruit of the Earth, Inc.
Galderma Laboratories, L.P.
Garam Of Nature
Genomma Lab
Genomma Lab USA Inc.
Glytone, LLC
Good for the Goose Products, LLC
Grace And Fire USA Inc.
Groupe Marcelle Inc.
Guanghzou AiXin Biotech Co., Ltd
Guangzhou Bo win Trade Co., Ltd.
Guangzhou Haishi Biological Technology Co., Ltd.
Guangzhou Senmai Biotechnology Co.
Guangzhou Senmai Biotechnology Co., Ltd.
Guangzhou Tata Biotechnology Co., Ltd.
Guinot
Gurwitch Products, LLC
Guthy-Renker LLC
Haleon US Holdings LLC
HAMEX GLOBAL COSMETICS LLC
Hampton Sun
Hangzhou Jingshen Trading Co., Ltd.
Have & Be Co., Ltd.
Hayden Caleel LLC
I World LLC
Innovation Brands Inc.
Intelligent Elixirs, LLC
ISNTREE Inc.
Jack Black, L.L.C.
June Jacobs Labs, LLC
Jungsaemmool Beauty Co., Ltd.
Kara Vita, Inc.
KAS Direct LLC dba BabyGanics
Kenvue Brands LLC
Kolmask Co., Ld.
KONAD CO LTD
KOS America, Inc.
KW ABSC, INC.
L'Bri Health & Beauty
L'Oreal USA Products Inc
Laboratoires Clarins
LABORATOIRES M&L
Laura Mercier US Buyer LLC
LG H&H Co., Ltd.
LG HOUSEHOLD & HEALTH CARE LTD.
Likewise Incorporated
Longway Technology(Guangzhou) Co., Ltd.
MAIDORA CO.,LTD
MAKEUP ART COSMETICS
MakingCosmetics Inc.
Mana Products
MANA PRODUCTS,INC.
Mary Kay Inc.
MAX HUBER RESEARCH LAB INC
Meaningful Beauty, LLC
Medline Industries, LP
MEIJER DISTRIBUTION INC
Melaleuca Inc.
Merle Norman Cosmetics, Inc
Merz North America, Inc
MJ Products Association, LLC
MONOGLOT HOLDINGS Inc.
NAKED SUNDAYS PTY LTD
Naples Soap Co.
Naples Soap Company, Inc.
NARS Cosmetics
NATURECELL CO., LTD.
Navajo Manufacturing Company Inc.
NeoStrata Company Inc.
New Milani Group, LLC
NING PTE. LTD.
Nippon Shikizai, Inc.
Noon Aesthetics M.R. Ltd
Noxell
Noxell Corporation
O&M HALYARD, INC.
Obagi Cosmeceuticals LLC
OraLabs
ORIGINS NATURAL RESOURCES INC.
Panama Jack
PARFUMS CHRISTIAN DIOR
Pelotan LLC
Person and Covey
PHARMAGEL INTERNATIONAL INC
Philosophy, Inc.
Premier Ocher LLC
Private Label Skin Care
Product Management LLC
Pur-lisse Beauty, LLC
Pure Source, LLC
PureTek Corporation
Quantum, Inc.
Qur, Inc
R & R Lotion, Inc
R&G Divergency LLC
Raining Rose
Raining Rose, Inc
RENU LABORATORIES, LLC
Retail Concepts of Minnesota, Inc
Revision, LLC
REVLON
REVLON CONSUMER PR Consumer Products Corp
REVLON CONSUMER PRODUCTS CORP
Rimmel
Robanda International, Inc.
Rodan & Fields
Rodial
Rodial Ltd.
Safetec of America, Inc.
SALICYLATES & CHEMICALS PRIVATE LIMITED
Sawyer Products Inc
SCIENCE OF SKINCARE LLC
SHISEIDO AMERICAS CORPORATION
SICOS ET CIE
Sinobest Cosmeceutical Co., Ltd.
Skin Ai, LLC
Skin Authority LLC
SKIN MEDICINALS LLC
Skin PS Brands
Skin Script, LLC
SKINMETICS INC
SkinScience Labs, Inc
SMASHBOX BEAUTY COSMETICS, INC
SnugZ/USA, LLC
Solazyme, Inc.
SOLVADERM LLC
Spa de Soleil
Space Brands Limited
Suave Brands Co., LLC
Sunstation USA, LLC
Susonity Production GmbH
Swiss-American CDMO, LLC
TAN ALIZE KOZMETIK VE TEMIZLIK URUNLERI SANAYI VE TICARET ANONIM SIRKETI
TARGET CORPORATION
THANK YOU FARMER CO., LTD
The Avon Company
The Center Brands, LLC
The Gorilla Glue Company/O'Keeffe's Company
The Lip Bar
The Mentholatum Company
The Milani Group, Inc.
The Procter & Gamble Manufacturing Company
THIS WORKS PRODUCTS LIMITED
TIEGE HANLEY, Inc
TOM FORD BEAUTY DIST
Topiderm, Inc.
Total Resources International
Trader Joe's Company
TriLipid Research Institute, LLC
Tropical Seas, Inc.
TT Fitness, Inc
USANA Health Sciences, Inc.
Vantage Specialty Ingredients, Inc.
Vege Labs
Vege Labs LLC
Velovita Inc.
Ventura Corporation LTD
Vi Medical Products, INC
Vivant Pharmaceuticals, LLC
Vivier Pharma Inc.
Walmart
Wilc Healthcare Inc
Yusef Manufacturing Laboratories
Zinka, Inc.
ZITSTICKA, Inc

Why It Matters

Sectors
Core ChemicalsHealth
Downstream Uses

Appears in 1542 drug and cosmetic product listings (FDA).

  • •Beeswax Lip Balm
  • •Cherry Lip Balm
  • •Vanilla Lip Balm
  • •Wildberry Lip Balm
  • •Jungsaemmool Essential Skin Nuder Cushion Fair
  • •Jungsaemmool Essential Skin Nuder Cushion Medium Deep
  • •Jungsaemmool Essential Skin Nuder Longwear Cushion Fair Light
  • •Tiege Hanley AM Morning Facial Moisturizer with SPF 20
FDA Shortage Status
No FDA shortage records

Industrial Uses

  • •Fragrance in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.13/gAA BLOCKS
CountryUnited States
Pack$64.00 / 500 g
Purity97%
Vendors3 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS5466-77-3
PubChem CID5355130
DTXSIDDTXSID1025302
FormulaC18H26O3
Mol. Weight290.4 g/mol
SMILESCCCCC(CC)COC(=O)C=CC1=CC=C(C=C1)OC

Data Sources

Brief citations

Octinoxate (CAS 5466-77-3) https://chemicalindependence.com/chemical/5466-77-3/ EPA CompTox (DSSTox): DTXSID1025302. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1025302 PubChem: 5355130. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/5355130 EPA Chemical Data Reporting: 5466-77-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 5466-77-3. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 291899 for CAS 5466-77-3. Reporting year: 2024. https://usatrade.census.gov/