Isocyclemone E

CAS 54464-57-2

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$150M

Top sourceIndia 25%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291429 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291429, which covers 163 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 25%IndiaES 18%SpainCN 12%ChinaIL 11%IsraelCH 9%Switzerland

Slovakia
Malaysia
Netherlands
Ukraine
Singapore
Brazil
Romania
United Kingdom
Cyprus
Canada

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Iff Chemical Holdings

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Reckitt Benckiser

EPA-registered importers (12)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Reckitt Benckiser Group · GB United Kingdom

Symrise Ag · DE Germany

Berje

Colgate-Palmolive

Givaudan Fragrances

Show all 12

Henkel Us Operations

International Flavors And Fragrances

P&G

S.C. Johnson & Son

Symrise

Takasago

Tilley Distribution

Why It Matters

Sectors

AgricultureMetals & MiningPlastics & RubberConsumer ProductsCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 8 sectors as 1 functional role.

•Fragrance in All Other Basic Organic Chemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Fragrance in Plastics Material and Resin Manufacturing (1%)Processing—incorporation into article
•Fragrance in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (5%)Processing—incorporation into formulation, mixture, or reaction product
•Fragrance in All Other Chemical Product and Preparation Manufacturing (15%)Processing—repackaging
•Fragrance in Not Known or Reasonably Ascertainable (100%)Not Known or Reasonably Ascertainable
•Fragrance in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (10%)Processing—incorporation into formulation, mixture, or reaction product
•Fragrance in Wholesale and Retail Trade (100%)Processing—incorporation into formulation, mixture, or reaction product
•Fragrance in Other (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.25/gCombi-Blocks, Inc.

CountryUnited States

Pack$250.00 / 1 kg

Purity95%

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$0.27	1 kg	95%
AA BLOCKS	United States	$0.28	1 kg	95%
Aaron Chemicals LLC	Hong Kong	$0.35	500 g	90%
Angene Chemical	China → Hong Kong	$0.38	500 g	90%
MedChemExpress MCE	Sweden	$0.81	500 g	—
Ambeed, Inc.	United States	$1.20	25 g	90%
AK Scientific, Inc.	United States	$2.29	100 g	95%
Angene International Limited	United States	$3.87	100 g	95%
Interbioscreen	Hong Kong	$170.00	10 g	95%
Angene	China → Hong Kong	$4266.67	30 mg	90%

Chemical Identity

CAS54464-57-2

PubChem CID108242

DTXSIDDTXSID7031290

FormulaC16H26O

Mol. Weight234.38 g/mol

SMILESCC1CC2=C(CC1(C)C(=O)C)C(CCC2)(C)C

Data Sources

EPA CompTox (DSSTox) · DTXSID7031290Retrieved 2026-04-06
PubChem · compound 108242Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Isocyclemone E (CAS 54464-57-2) https://chemicalindependence.com/chemical/54464-57-2/ EPA CompTox (DSSTox): DTXSID7031290. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7031290 PubChem: 108242. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/108242 EPA Chemical Data Reporting: 54464-57-2. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 54464-57-2. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291429 for CAS 54464-57-2. Reporting year: 2024. https://usatrade.census.gov/