4,4-Dimethoxybutanone

CAS 5436-21-5

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$85M

Top sourceChina 53%

At least one company claimed its 2019 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291450 · basket

EPA reports by year

2023: US production Not published · Imports Not published
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291450, which covers 68 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 53%ChinaIN 25%IndiaMX 9%MexicoDE 7%GermanyIT 4%Italy

Switzerland
Taiwan
South Korea
Canada
United Kingdom
Ukraine
Hong Kong
Romania
Austria
Spain
Lithuania

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Corteva

Mitsubishi Corp (Americas)

Why It Matters

Sectors

Agriculture

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (100%)Processing as a reactant

Vendor Pricing

$0.05/gAaron Chemicals LLC

CountryHong Kong

Pack$27.00 / 500 g

Purity92%

Vendors18 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

17 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.06	1 kg	92%
Manchester Organics	United Kingdom	$0.11	5 kg	90%
Chemscene	United States	$0.14	500 g	—
Ambeed, Inc.	United States	$0.16	500 g	90%
A2B Chem LLC	United States	$0.21	100 g	85%
AA BLOCKS	United States	$0.23	100 g	85%
MedChemExpress MCE	Sweden	$0.25	500 g	95.84%
Combi-Blocks, Inc.	United States	$0.25	1 kg	96%
AstaTech, Inc	United States	$0.27	100 g	90%
ALFA AESAR	Germany	$0.46	1 kg	90%
Synthonix	United States	$0.80	25 g	90%
Angene International Limited	United States	$1.13	100 g	90%
Apollo Scientific US	United Kingdom	$4.20	5 g	95%
Interbioscreen	Hong Kong	$10.00	10 g	95%
Otava, Ltd.	Ukraine	$10.40	2.5 g	95%
HTS Biochemie Innovationen	Germany	$170.00	5 g	95%
Angene	China → Hong Kong	$4266.67	30 mg	92%

Chemical Identity

CAS5436-21-5

PubChem CID228548

DTXSIDDTXSID8052196

FormulaC6H12O3

Mol. Weight132.16 g/mol

SMILESCC(=O)CC(OC)OC

Data Sources

EPA CompTox (DSSTox) · DTXSID8052196Retrieved 2026-04-06
PubChem · compound 228548Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

4,4-Dimethoxybutanone (CAS 5436-21-5) https://chemicalindependence.com/chemical/5436-21-5/ EPA CompTox (DSSTox): DTXSID8052196. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID8052196 PubChem: 228548. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/228548 EPA Chemical Data Reporting: 5436-21-5. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 5436-21-5. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291450 for CAS 5436-21-5. Reporting year: 2024. https://usatrade.census.gov/