Tofacitinib citrate

Drug ingredient

CAS 540737-29-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

27 FDA-registered drug labelers

Alivus Life Sciences Limited

Almon Healthcare Private Limited

Aurore Pharmaceuticals Private Limited

AX Pharmaceutical Corp

Chunghwa Chemical Sysnthsis & Biotech Co.,Ltd.

DARMERICA, LLC

DELMAR CHEMICALS INC

Dr. Reddy's Laboratories Limited

Honour Lab Limited

Hunan Jiudian Pharmaceutical Co.,Ltd.

Lee Pharma Limited

Matrix Pharmacorp Private Limited

Metrochem API Private Limited

Micro Labs Limited

MSN Laboratories Private Limited

Nantong Chanyoo Pharmatech Co., Ltd

Olon S.p.A.

Pfizer Asia Manufacturing Pte Ltd

Pfizer Ireland Pharmaceuticals Unlimited Company

Pfizer Laboratories Div Pfizer Inc

Qingdao Biopeptek Co., Ltd.

SUN PHARMACEUTICAL INDUSTRIES, INC.

U.S. Pharmaceuticals

Unichem Laboratories Limited, India

Zhejiang Ausun Pharmaceutical Co., Ltd.

Zhejiang Huahai Pharmaceutical Co., Ltd.

Zydus Lifesciences Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Xeljanz XR
•Xeljanz

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS540737-29-9

PubChem CID10174505

DTXSIDDTXSID80202404

FormulaC22H28N6O8

Mol. Weight504.5 g/mol

SMILESCC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Data Sources

PubChem · compound 10174505Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tofacitinib citrate (CAS 540737-29-9) https://chemicalindependence.com/chemical/540737-29-9/ PubChem: 10174505. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/10174505 FDA National Drug Code directory: CAS 540737-29-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 540737-29-9. Reporting year: 2024. https://usatrade.census.gov/