Etonogestrel

Drug ingredient

CAS 54048-10-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$76M

Top sourceSpain 35%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293723 · basket

These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary

Canada
United Kingdom
Taiwan

17 FDA-registered drug labelers

A-S Medication Solutions

Advanz Pharma (US) Corp.

Amneal Pharmaceuticals LLC

Aspen Oss B.V.

AvKARE

Curia Spain S.A.U.

Gedeon Richter Plc.

Industriale Chimica s.r.l.

N.V. Organon

Northstar Rx LLC

Organon LLC

Prasco Laboratories

STERLING SPA

Steroid S.p.A.

Synergy Health AST, LLC

Teva Pharmaceuticals USA, Inc.

Xiromed, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 8 drug and cosmetic product listings (FDA).

•Etonogestrel and Ethinyl Estradiol Vaginal
•EnilloRing
•Nuvaring
•Etonogestrel/Ethinyl Estradiol
•Etonogestrel and Ethinyl Estradiol
•Nexplanon
•Etonogestrel and Ethinyl Estradiol Vaginal Ring
•EluRyng

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Ethinyl Estradiol; Etonogestrel Ring
Shortage listed since June 16, 2025

See all current drug shortages

Chemical Identity

CAS54048-10-1

PubChem CID6917715

DTXSIDDTXSID9046782

FormulaC22H28O2

Mol. Weight324.5 g/mol

SMILESCCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34

Data Sources

PubChem · compound 6917715Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Etonogestrel (CAS 54048-10-1) https://chemicalindependence.com/chemical/54048-10-1/ PubChem: 6917715. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6917715 FDA National Drug Code directory: CAS 54048-10-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 54048-10-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293723 for CAS 54048-10-1. Reporting year: 2024. https://usatrade.census.gov/