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Aminopterin

CAS 54-62-6

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-

Molecular structure of 54-62-6
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Why It Matters

No EPA sector or FDA product records name a use for this chemical.

Chemical Identity

CAS54-62-6
PubChem CIDNot recorded
DTXSIDDTXSID3022588
FormulaC19H20N8O5
Mol. Weight440.42 g/mol
SMILESNC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=N2)C(N)=N1

Data Sources

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Brief citations

Aminopterin (CAS 54-62-6) https://chemicalindependence.com/chemical/54-62-6/ EPA TSCA Inventory: CAS 54-62-6. Retrieved 2026-10-04. https://www.epa.gov/tsca-inventory US Census international trade: HS 293359 for CAS 54-62-6. Reporting year: 2024. https://usatrade.census.gov/