penicillin g procaine

Drug ingredient

CAS 54-35-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$78M

Top sourceItaly 33%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294110 · basket

These shares come from HS customs code 294110, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 33%ItalyCN 31%ChinaBG 22%BulgariaES 8%SpainMX 3%Mexico

Singapore
Israel
Germany
South Korea
Hong Kong
Japan
Switzerland

4 FDA-registered drug labelers

CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.

Fersinsa GB, S.A. de C.V.

Pfizer Laboratories Div Pfizer Inc

Sandoz GmbH

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Bicillin CR
•Bicillin C-R 900/300

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS54-35-3

PubChem CID5903

DTXSIDDTXSID30883227

FormulaC29H38N4O6S

Mol. Weight570.7 g/mol

SMILESCCN(CC)CCOC(=O)C1=CC=C(C=C1)N.CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C

Data Sources

PubChem · compound 5903Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

penicillin g procaine (CAS 54-35-3) https://chemicalindependence.com/chemical/54-35-3/ PubChem: 5903. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5903 EPA TSCA Inventory: CAS 54-35-3. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 294110 for CAS 54-35-3. Reporting year: 2024. https://usatrade.census.gov/