nicotine
Drug ingredientCAS 54-11-5
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Import value, 2024$630M
Top sourceGermany 28%
This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293979, 380891 · basket
These shares come from HS customs code 293979, 380891, which covers 69 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
DE 28%GermanyCH 12%SwitzerlandCN 11%ChinaMX 11%MexicoIN 8%India
- Austria
- Malaysia
- United Kingdom
- Sweden
- Dominican Republic
- Spain
- Czech Republic
- South Africa
- Portugal
- Australia
- Colombia
- Belgium
- Philippines
- Turkey
- New Zealand
- Peru
- Uruguay
- Costa Rica
- Kenya
- Slovenia
- Monaco
- El Salvador
- Chile
- Panama
- Hong Kong
105 FDA-registered drug labelers
A-S Medication Solutions
AAFES/Your Military Exchanges
Advagen Pharma Limited
Alchem International Private Ltd
Amazon.com Services LLC
American Sales Company
Amerisource Bergen
AmerisourceBergen (Good Neighbor Pharmacy) 46122
AmerisourceBergen Drug Corporation
Army & Air Force Exchange Service
Ash Ingredients, Inc.
ATLANTIC BIOLOGICALS CORP.
Aurohealth LLC
Aveva Drug Delivery Systems Inc.
BGP Healthcare Private Limited
BJWC
BLIP PRODUCTS, INC.
BluePoint Laboratories
Boiron
Bryant Ranch Prepack
Cambrex Charles City, Inc
Cardinal Health
Cardinal Health (Leader) 70000
CARDINAL HEALTH 110, LLC. DBA LEADER
Catalent Pharma Solutions, LLC
Chain Drug Consortium, LLC
Chain Drug Marketing Association INC
Costco Wholesale Company
CVS Pharmacy
CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED
Dolgencorp Inc
Dolgencorp, Inc. (DOLLAR GENERAL & REXALL)
DOLGENCORP, LLC
Dongkou County Hecheng Network Technology Co., Ltd.
Dr. Reddy's Laboratories Inc.
EQUATE (Wal-Mart Stores, Inc.) (see also WAL-MART INC)
EXELAN PHARMACEUTICALS, INC.
Family Dollar (FAMILY WELLNESS)
Fertin Pharma A/S
Golden State Medical Supply, Inc.
Guangxi Keyun E-commerce Co., Ltd.
Guangzhou Ouruisi Biotechnology Co., Ltd
Guangzhou Shuimu Jiahe Trading Co., Ltd.
Guangzhou Yixin Cross-border E-commerce Co., Ltd.
H E B
Haleon US Holdings LLC
Hansen Pharmaceutical Investment Co., Limited
Harman Finochem Limited
HC Jones, Inc.
Henan Jiugao Cross-border Ecommerce Co., Ltd.
Hengyang Chuangjiujia Trading Co., Ltd.
HyVee Inc
Jiangxi Yudexi Pharmaceutical Co., LTD
Jiashen International Trade Limited
Kroger Company
L Perrigo Company
Lil' Drug Store Products, Inc.
Lucy Goods, Inc.
McKesson Corporation dba SKY Packaging
McNeil AB
Medline Industries, LP
Meijer Distribution Inc
Meijer, Inc.
Nanjing Ludejin Corporation Management Co., Ltd
Newton Laboratories, Inc.
Nico Orgo Marketing Pvt Ltd
Nicobrand LTD
NuCare Pharmaceuticals, Inc.
P & L Development, LLC
Padagis Israel Pharmaceuticals Ltd
PCHEERY LLC
Pharmacia & Upjohn Company LLC
PLD Acquisitions LLC DBA Avma Pharma Solutions
Porton Pharma Solutions Ltd
Professional Complementary Health Formulas
Professional Compounding Centers of America dba PCCA
Publix Super Markets Inc
QUITINE LLC
Rising Pharma Holdings, Inc.
Rite Aid Corporation
Rugby Laboratories
Rugby Laboratories, Inc.
Safeway
Sam's West Inc
Shenzhen Hengdasheng Technology Co., Ltd
Shenzhen Paxi Trading Co., Ltd.
Shenzhen Shandian Jingling Technology Co., Ltd.
Shenzhen TeLaFaErJiaLuo Technology Co., Ltd.
Shenzhen Xinxin Yunhai Technology Co., Ltd.
Shenzhen Yadifei Trading Co., Ltd.
Siegfried AG
Strategic Sourcing Services LLC
Target Corporation
The Kroger Co.
Topco Associates LLC
Vitality Works, Inc.
Wal-Mart Stores Inc
Walgreen Company
Walgreens
Walgreens Company
WALMART INC.
WALMART INC. (see also Equate)
Xinsno Technology (Shenzhen) Co., Ltd
YITONGBADA (SHENZHEN) INTERNATIONAL TRADE CO., LTD
Zhejiang FTA Shengzuozhi Biotechnology Co., LTD
Why It Matters
Sectors
Health
Downstream Uses
Appears in 144 drug and cosmetic product listings (FDA).
- •Nicotine Polacrilex
- •basic care nicotine
- •Nicotine transdermal system step 1
- •Habitrol Nicotine Polacrilex Gum 2 mg Coated Mint
- •Habitrol Nicotine Polacrilex Gum 4 mg Coated Mint
- •Nicotine
- •Rugby Nicotine Polacrilex Gum, Mint Flavor
- •Up and Up Mini Nicotine
Show all 144
- •up and up mint nicotine
- •BLIP
- •Sielkin QUIT Smoking Nicotine Patches 14mg
- •quitine nicotine
- •QUIT Smoking Nicotine Patches
- •Nicotine Patches
- •Aroamas COT Nicotine Transdermal Patches STEP 2
- •Wofanli Quit Smoking Nicotine Patches
- •NicDuic Quit Smoking Nicotine Patches 1 Step
- •quit smoking patches
- •QUIT Smoking 7mg
- •QUIT Smoking 14mg
- •nictoine gum
- •Mini Nicotine
- •Rugby Nicotine Polacrilex Gum, Original Flavor
- •Good Sense Nicotine
- •Topcare Nicotine
- •Nicorette Cinnamon Surge
- •Nicorette White Ice Mint
- •Nicorette
- •Nicorette Cherry Peppermint
- •careone nicotine
- •Nicotine transdermal system step 3
- •Habitrol Lozenge Cherry
- •good neighbor pharmacy nicotine mini
- •Nicotine Mini
- •equate nicotine
- •Nicotrol
- •Tobacco Withdrawal
- •Nicotine Polacrilex Coated Mint
- •Nicotine transdermal system step 2
- •Nicotine Polacrilex Lozenge Mint
- •kirkland signature quit 4
- •members mark nicotine
- •Nicotine transdermal system
- •foster and thrive nicotine
- •up and up citrus mini nicotine
- •Sielkin QUIT Smoking Nicotine Patches
- •signature care nicotine
- •Nicorette Mint
- •Nicorette Spearmint Burst
- •Nicorette Peppermint
- •Habitrol Nicotine Polacrilex Lozenge Mint
- •Good Neighbor Pharmacy Nicotine
- •Nicotine Polacrilex coated ice mint
- •berkley and jensen nicotine
- •Nicotine Sugar Free
- •foster and thrive STEP 2
- •foster and thrive STEP 1
- •Amazon Basic CARE Nicotine Polacrilex
- •quitine mini nicotine
- •Nicotine STOP Smoking AID
- •Rbugr QUIT Smoking Nicotine Patches
- •Nicorette Original
- •Nicoderm CQ
- •HEB Nicotine
- •Medline
- •Nicotinum
- •exchange select nicotine
- •Habitrol Nicotine Polacrilex 2 mg Coated Cinnamon
- •Habitrol Step 3
- •Nicotine Polacrilex Origianl Flavor
- •Kirkland Signature Quit 2
- •Nicorette 4mg Cinnamon Surge
- •Maxi Nicotine
- •foster and thrive STEP 3
- •Rugby Nicotine Polacrilex Gum, Coated Mint Flavor
- •Rugby Nicotine Polacrilex Gum, Coated Fruit Flavor
- •up and up cherry ice nicotine
- •up and up uncoated nicotine
- •UP AND UP Coated Cinnamon Nicotine
- •Up and Up Nicotine
- •up and up uncoated mint nicotine
- •UP AND UP Coated Fruit Nicotine
- •Sielkin QUIT Smoking Nicotine Patches 21mg
- •Rstrvbr QUIT Smoking
- •dg health nicotine
- •coated nicotine
- •Anti-Smoking I Drops 2007
- •Anti-Smoking II Drops 2008
- •Nicorette 4mg Fruit Chill Gum, Lil Drug Store
- •Nicotine Polacrilex, Original
- •berkley and jensen nicotine polacrilex
- •Nicotine Polacrilex coated fruit
- •Nicotine Polacrilex coated cinnamon
- •euqate nicotine
- •UP AND UP Coated MINT Freeze Nicotine
- •up and up uncoated original nicotine
- •up and up cherry nicotine
- •up and up coated cool mint nicotine
- •Elsophie Nicotine Patches Quit
- •NicDuic Quit Smoking Nicotine Patches
- •Stpsmk QUIT Smoking Nicotine Patches
- •Guhio Nicotine Patch
- •QUIT Smoking 21mg
- •Nicotine Oral Pouch
- •Nicorette Fruit Chill
- •nicotine lozenge
- •GOOD Sense
- •Nicotine Polacrilex Original Flavor
- •Nicotine Polacrilex Gum
- •Kirkland Signature Nicotine
- •Nicotine Polacrilex MINT
- •up and up mint mini nicotine
- •Sefudun QUIT Smoking Nicotine Patches
- •Hqlsey QUIT Smoking Patches
- •Nicorette Fruit Chill nicotine polacrilex
- •Habitrol Lozenge Original Flavor
- •Habitrol Step 2
- •Rexall Nicotine
- •Serynth Nicotine Transdermal STOP Smoking AID
- •NicDuic Quit Smoking Nicotine Patches 2 Step
- •CareOne Mini Nicotine Polacrilex
- •Habitrol Nicotine Polacrilex Gum 2 mg Coated Fruit
- •NWRB Nicotine Transdermal Patch
- •QUIT Smoking Proven Patches
- •Aroamas COT Nicotine Transdermal Patches STEP 1
- •Aroamas COT Nicotine Transdermal Patches STEP 3
- •Choppie Nicotine
- •nicotine mint flavor
- •Nicorette 4mg White Ice Mint Gum, Lil Drug Store
- •members mark mini nicotine
- •Habitrol Nicotine Polacrilex Gum 4 mg Coated Fruit
- •Aroamas Cot Nicotine Transdermal Patches Kit
- •NicDuic Quit Smoking Nicotine Patches 3 Step
- •good sense nicotine mint
- •Nicorette White Mint nicotine polacrilex
- •topcare nicotine polacrilex
- •Habitrol Step 1
- •up and up nicotine mini mint
- •Flobow QUIT Smoking Nicotine
- •SENO Oral film
- •NicDuic Quit Smoking Nicotine Patches 1-3 Step
- •Habitrol Nicotine Polacrilex 4 mg Coated Cinnamon
- •stop smoking aid
- •L-Trans
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Chemical Identity
CAS54-11-5
PubChem CID89594
DTXSIDDTXSID1020930
FormulaC10H14N2
Mol. Weight162.23 g/mol
SMILESCN1CCCC1C2=CN=CC=C2
Data Sources
- PubChem · compound 89594Retrieved 2026-04-07
- EPA TSCA InventoryRetrieved 2026-04-24
- FDA National Drug Code directoryRetrieved 2026-04-07
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
nicotine (CAS 54-11-5) https://chemicalindependence.com/chemical/54-11-5/ PubChem: 89594. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/89594 EPA TSCA Inventory: CAS 54-11-5. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293979,380891 for CAS 54-11-5. Reporting year: 2024. https://usatrade.census.gov/