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Sirolimus

Drug ingredient

CAS 53123-88-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 53123-88-9
US productionNot reported
Import value, 2024$6.4B
Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India
42 FDA-registered drug labelers
Aadi Bioscience, Inc.
American Health Packaging
Amneal Pharmaceuticals NY LLC
Apotex Corp
Ascend Laboratories, LLC
AvPAK
AX Pharmaceutical Corp
Biocon Limited
Camber Pharmaceuticals, Inc.
Chongqing Daxin Pharmaceutical Co. Ltd.
Chunghwa Chemical Synthesis & Biotech. Ltd
CONCORD BIOTECH LTD
Curia Italy S.r.l.
Darmerica, LLC
Dr. Reddy's Laboratories Limited
Fujian Kerui Pharmaceutical Co., Ltd.
Glenmark Pharmaceuticals Inc., USA
Hisun Pharmaceutical (Hangzhou) Co., Ltd.
LETCO MEDICAL, LLC
Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
Lonza AG
Major Pharmaceuticals
Medterials, Inc
Mylan Pharmaceuticals Inc.
Nobelpharma America, LLC
North China Pharmaceutical Huasheng Co. Ltd.
NORTHSTAR RX LLC
Novadoz Pharmaceuticals LLC
Novo Nordisk Production Ireland Limited
Patheon Inc.
Pfizer Ireland Pharmaceuticals Unlimited Company
Pharma Source Direct, Inc.
Qingdao Biopeptek Co., Ltd.
Qingdao Qinzeyuan Biotechnology Co., Ltd
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Sumar Biotech LLP
Suresource Pharma LLC
VistaPharm, LLC
Zhejiang Wild Wind Pharmaceutical Co.,Ltd.
Zydus Lifesciences Limited
Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •sirolimus
  • •Hyftor
  • •Fyarro
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS53123-88-9
PubChem CID5284616
DTXSIDDTXSID5023582
FormulaC51H79NO13
Mol. Weight914.2 g/mol
SMILESCC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC

Data Sources

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Brief citations

Sirolimus (CAS 53123-88-9) https://chemicalindependence.com/chemical/53123-88-9/ PubChem: 5284616. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5284616 FDA National Drug Code directory: CAS 53123-88-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 53123-88-9. Reporting year: 2024. https://usatrade.census.gov/