Indomethacin

Drug ingredient

CAS 53-86-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 53-86-1
US productionNot reported
Import value, 2024$1.4B
Top sourceIreland 33%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293399 · basket

These shares come from HS customs code 293399, which covers 518 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 33%IrelandCN 26%ChinaIN 11%IndiaDE 9%GermanyIT 4%Italy
37 FDA-registered drug labelers
A-S Medication Solutions
Advanced Rx Pharmacy of Tennessee, LLC
Agno Pharma Jiangsu
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals NY LLC
ANI Pharmaceuticals, Inc.
Asclemed USA, Inc.
Aurore Pharmaceuticals Private Limited
AvPAK
AX Pharmaceutical Corp
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Chartwell RX, LLC
DIRECT RX
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
Fresenius Kabi USA, LLC
Glenmark Pharmaceuticals Inc., USA
Hetero Drugs Limited
Hikma Pharmaceuticals USA Inc.
KVK-Tech, Inc.
Macleods Pharmaceuticals Limited
NorthStar RxLLC
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
PD-Rx Pharmaceuticals, Inc.
Preferred Pharmaceuticals Inc.
Proficient Rx LP
RedPharm Drug, Inc.
REMEDYREPACK INC.
Sportpharm LLC
ST. MARY'S MEDICAL PARK PHARMACY
XLCare Pharmaceuticals Inc.
Zydus Lifesciences Limited
Zydus Pharmaceuticals USA Inc.
Zyla Life Sciences US Inc.
Zyla Life Sciences US LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Indomethacin
  • •Indomethacin ER
  • •Indocin
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.14/gAaron Chemicals LLC
CountryHong Kong
Pack$72.00 / 500 g
Purity97%
Vendors31 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS53-86-1
PubChem CID3715
DTXSIDDTXSID9020740
FormulaC19H16ClNO4
Mol. Weight357.8 g/mol
SMILESCC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Data Sources

Brief citations

Indomethacin (CAS 53-86-1) https://chemicalindependence.com/chemical/53-86-1/ PubChem: 3715. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/3715 EPA TSCA Inventory: CAS 53-86-1. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293399 for CAS 53-86-1. Reporting year: 2024. https://usatrade.census.gov/