Methylprednisolone acetate

Drug ingredientActive Shortage

CAS 53-36-1

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$154M

Top sourceItaly 60%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293729 · basket

These shares come from HS customs code 293729, which covers 57 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 60%ItalyES 14%SpainCN 11%ChinaDE 6%GermanyAT 2%Austria

Netherlands
Australia
Malaysia
Portugal
United Kingdom
Japan
Malta
Canada
Israel
Singapore
New Zealand
Poland
Ukraine
Belgium
Sweden

27 FDA-registered drug labelers

A-S Medication Solutions

Amneal Pharmaceuticals LLC

Amneal Pharmaceuticals NY LLC

Asclemed USA, Inc.

Caplin Steriles Limited

Curia Spain S.A.U.

Endo USA, Inc.

Eugia US LLC

EUROAPI FRANCE

Fagron Inc

Farmabios S.p.A.

Henan Lihua Pharmaceutical Co Ltd

LETCO MEDICAL, LLC

Medisca Inc.

NEWCHEM SPA

Pharmacia & Upjohn Company LLC

Pharmacia and Upjohn Company LLC

Professional Compounding Centers of America dba PCCA

Sagent Pharmaceuticals

Sandoz Inc.

Sotera Health

Spectrum Laboratory Products, Inc.

Sportpharm LLC

Symbiotec Pharmalab Limited

Symbiotica Speciality Ingredients Sdn. Bhd.

Willow Birch Pharma, Inc.

Zhejiang Xianju Pharmaceutical Co., Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•DEPO-Medrol
•Methylprednisolone acetate
•Medroloan SUIK
•Medroloan II SUIK

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Methylprednisolone Acetate Injection
Shortage listed since December 15, 2021
Manufacturer reports: 2 unavailable, 1 limited, 1 available

See all current drug shortages

Chemical Identity

CAS53-36-1

PubChem CID5877

DTXSIDDTXSID7023302

FormulaC24H32O6

Mol. Weight416.5 g/mol

SMILESCC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)C)O

Data Sources

PubChem · compound 5877Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Methylprednisolone acetate (CAS 53-36-1) https://chemicalindependence.com/chemical/53-36-1/ PubChem: 5877. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5877 FDA National Drug Code directory: CAS 53-36-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 53-36-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293729 for CAS 53-36-1. Reporting year: 2024. https://usatrade.census.gov/