Flag of the United StatesAmerican Chemical Independence

cocaine hydrochloride

Drug ingredient

CAS 53-21-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 53-21-4
1 HCl
US productionNot reported
Import value, 2024$89K
Top sourceGermany 56%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293972 · basket

These shares come from HS customs code 293972, which is a broad customs category that also covers chemicals outside this dataset. They estimate the category's origin mix, not this chemical specifically.

Source Countries
DE 56%GermanyCA 20%CanadaIT 14%ItalyCH 10%Switzerland
5 FDA-registered drug labelers
LXO US INC.
MEDISCA Inc.
OMNIVIUM PHARMACEUTICALS LLC.
SpecGx LLC
Spectrum Laboratory Products, Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

  • •cocaine hydrochloride nasal
  • •Numbrino
  • •Goprelto
  • •Cocaine Hydrochloride
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS53-21-4
PubChem CID656832
DTXSIDDTXSID2048903
FormulaC17H22ClNO4
Mol. Weight339.8 g/mol
SMILESCN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC.Cl

Data Sources

← Back to Dashboard← Back to Health

Brief citations

cocaine hydrochloride (CAS 53-21-4) https://chemicalindependence.com/chemical/53-21-4/ PubChem: 656832. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/656832 FDA National Drug Code directory: CAS 53-21-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293972 for CAS 53-21-4. Reporting year: 2024. https://usatrade.census.gov/