Estrone

Drug ingredient

CAS 53-16-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 53-16-7
US productionNot reported
Import value, 2024$76M
Top sourceSpain 35%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293723 · basket

These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary
24 FDA-registered drug labelers
Apex Energetics Inc.
BioActive Nutritional
BioActive Nutritional, Inc
Boiron
DARMERICA, LLC
Deseret Biologicals
Deseret Biologicals, Inc
DMD Clinical Naturopathy
Dr. Donna Restivo DC
Energetix Corp
Energetix Corporation
Energique, Inc.
Homeocare Laboratories
Kalchem International inc
Laboratoires Boiron
Newton Laboratories, Inc.
Pro Weight Loss Inc.
ProBLEN
Professional Compounding centers of America
Qinhuangdao Zizhu Pharmaceutical Co., Ltd.
Supplement Clinic, LLC.
Symbiotec Pharmalab Limited
White Manufacturing Inc. BDA Micro-West
White Manufacturing Inc. DBA Micro-West

Why It Matters

Sectors
Health
Downstream Uses

Appears in 39 drug and cosmetic product listings (FDA).

  • •Cand Plus
  • •Progenite
  • •EstroPRO Homeopathic Organotherapy
  • •Female Balance
  • •Strength F
  • •Chemstat
  • •Menstrual - PMS
  • •Cyclease PMS
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.85/gAaron Chemicals LLC
CountryHong Kong
Pack$425.00 / 500 g
Purity98%
Vendors30 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS53-16-7
PubChem CID5870
DTXSIDDTXSID4022367
FormulaC18H22O2
Mol. Weight270.4 g/mol
SMILESCC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O

Data Sources

Brief citations

Estrone (CAS 53-16-7) https://chemicalindependence.com/chemical/53-16-7/ PubChem: 5870. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5870 EPA TSCA Inventory: CAS 53-16-7. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293723 for CAS 53-16-7. Reporting year: 2024. https://usatrade.census.gov/