1,2,3,5-Tetramethylbenzene

CAS 527-53-7

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$68M

Top sourceIndia 35%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 290290 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Not published · Imports Not published

These shares come from HS customs code 290290, which covers 171 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 35%IndiaTW 11%TaiwanES 10%SpainDE 10%GermanyCN 8%China

Czech Republic
Netherlands
Switzerland
Pakistan
United Kingdom
Austria
Denmark
Indonesia
Lithuania
Hong Kong
Finland

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Crh Americas

Why It Matters

Sectors

Construction

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$9.24/gAngene Chemical

CountryChina (registered: Hong Kong)

Pack$231.00 / 25 g

Purity98%

Vendors12 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

11 more vendors

Vendor	Country	$/g	Pack	Purity
Combi-Blocks, Inc.	United States	$10.00	25 g	98%
Aaron Chemicals LLC	Hong Kong	$10.32	25 g	98%
BLD Pharmatech GmbH	Germany	$11.48	25 g	98%
BLD Pharmatech Ltd.	China	$11.48	25 g	98%
A2B Chem LLC	United States	$11.60	5 g	98%
AA BLOCKS	United States	$12.80	5 g	98%
Ambeed, Inc.	United States	$16.20	5 g	98%
AstaTech (2 weeks)	United States	$31.64	25 g	95%
Labotest KG	Germany	$217.80	5000 mg	90%
TargetMol Chemicals	China → United States	$500.00	100 mg	97.72%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS527-53-7

PubChem CID10695

DTXSIDDTXSID6026119

FormulaC10H14

Mol. Weight134.22 g/mol

SMILESCC1=CC(=C(C(=C1)C)C)C

Data Sources

EPA CompTox (DSSTox) · DTXSID6026119Retrieved 2026-04-06
PubChem · compound 10695Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

1,2,3,5-Tetramethylbenzene (CAS 527-53-7) https://chemicalindependence.com/chemical/527-53-7/ EPA CompTox (DSSTox): DTXSID6026119. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026119 PubChem: 10695. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/10695 EPA Chemical Data Reporting: 527-53-7. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 527-53-7. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290290 for CAS 527-53-7. Reporting year: 2024. https://usatrade.census.gov/