Propranolol

Drug ingredientActive Shortage

CAS 525-66-6

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$197M

Top sourceChina 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292219 · basket

These shares come from HS customs code 292219, which covers 167 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 36%ChinaIT 15%ItalyDE 14%GermanyIN 7%IndiaHU 5%Hungary

Saudi Arabia
Lithuania
Canada
Ukraine
Israel
Singapore
Mexico
Ireland
Netherlands
Malaysia
Slovakia
Denmark
Finland
Latvia
Greece
Austria

1 FDA-registered drug labeler

Adare Pharmaceuticals Inc

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Propranolol Hydrochloride Injection
Shortage listed since October 31, 2023
Manufacturer reports: 1 unavailable, 1 available

See all current drug shortages

Vendor Pricing

$25.60/gCombi-Blocks, Inc.

CountryUnited States

Pack$640.00 / 25 g

Purity98%

Vendors12 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

11 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$27.20	25 g	98%
AA BLOCKS	United States	$28.72	25 g	98%
Life Chemicals Inc.	Ukraine → Canada	$112.00	250 mg	95%
MedChemExpress MCE	Sweden	$225.06	5 g	99.91%
Aaron Chemicals LLC	Hong Kong	$420.00	250 mg	98%
Angene Chemical	China → Hong Kong	$456.00	250 mg	98%
Fulfilled by Molport	Latvia	$560.00	50 mg	90%
Angene International Limited	United States	$569.00	5 g	98%
AstaTech, Inc	United States	$878.00	1 g	95%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	97%
Asinex	Netherlands	$23232.00	10 mg	90%

Chemical Identity

CAS525-66-6

PubChem CID4946

DTXSIDDTXSID6023525

FormulaC16H21NO2

Mol. Weight259.34 g/mol

SMILESCC(C)NCC(COC1=CC=CC2=CC=CC=C21)O

Data Sources

PubChem · compound 4946Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Propranolol (CAS 525-66-6) https://chemicalindependence.com/chemical/525-66-6/ PubChem: 4946. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4946 FDA National Drug Code directory: CAS 525-66-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 525-66-6. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 292219 for CAS 525-66-6. Reporting year: 2024. https://usatrade.census.gov/