Tetrahydrozoline hydrochloride
Drug ingredientCAS 522-48-5
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Import value, 2024$114M
Top sourceChina 26%
This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293329 · basket
These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy
- Australia
- Brazil
- Czech Republic
- Ireland
- Sweden
- Ukraine
- Poland
- United Arab Emirates
- Hungary
- Israel
- Netherlands
- Canada
- Saudi Arabia
- Greece
- Belgium
- Austria
- Latvia
- Singapore
- Denmark
64 FDA-registered drug labelers
4 Trees, LLC
Altaire Pharmaceuticals Inc.
American Sales Company
Amerisource Bergen Drug Corp.
AmerisourceBergen
AmerisourceBergen Drug Corporation
Army and Air Force Exchange Service
Best Choice (Valu Merchandisers Company)
Better Living Brands LLC
Cardinal Health
CARDINAL HEALTH 110, LLC. DBA LEADER
Chain Drug Marketing Assoc., Inc.
Chain Drug Marketing Association, Inc.
CVS Pharmacy, Inc.
Discount Drug Mart
Discount Drug Mart, Inc.
DLC Laboratories, Inc.
Dolgencorp LLC
Family Dollar Services, Inc.
Geiss, Derstin & Dunn, Inc.
Geiss, Destin & Dunn, Inc.
Harris Teeter, LLC
Harris Teeter, LLC.P
HEB Grocery Company, LP
KC Pharmaceuticals
KC Pharmaceuticals, Inc.
Kenvue Brands LLC
Kinray
Kroger
Kroger Company
Liberty Procurement Co., Inc.
Lil Drug Store Products, Inc
Meijer Distribution, Inc.
Meijer, Inc.
Misemer Pharmaceutical, Inc
Morning Star OTC
Navajo Manufacturing Company Inc.
New World Imports, Inc
PCAS Finland Oy
Preferred PHarmaceuticals Inc.
Prestige Brands Holdings, Inc.
Prodose, Inc.
Publix Super Markets, Inc.
Quality Choice
Retail Business Services, LLC.
Rite Aid Corporation
Salado Sales, Inc.
Societa Italiana Medicinali Scandicci S.I.M.S., SrL
Sportpharm LLC
Strategic Sourcing Services LLC
The Kroger Co.
The Mentholatum Company
Topco Associates LLC
United Exchange Corp
United Natural Foods, Inc.
Valu Merchandisers Company
Valu Merchandisers, Co.
W. R. GRACE & CO.-CONN.
Walgreen Co.
Walgreen Company
Walgreens Company
Walmart
Walmart, Inc.
WinCo Foods, LLC
Why It Matters
Sectors
Health
Downstream Uses
Appears in 95 drug and cosmetic product listings (FDA).
- •Equate Multi-Symptom Relief Eye Drops
- •Equaline Multi-Symptom Eye Drops
- •Rohto Digi-Eye
- •Good Neighbor Pharmacy Eye Drops Advanced Relief
- •Equaline Advanced Relief Eye Drops
- •GNP Eye Drops Seasonal Relief
- •Sunmark Eye Drops Advanced Moisturizer/Lubricant
- •GoodSense Eye Drops Original Formula
Show all 95
- •Careall Eyedrops Original
- •Visine Red Eye Hydrating Comfort Eye Drops
- •Medics Choice Eye Drops Original Redness Reliever
- •DG Health Advanced Relief Eye Drops
- •Family Care Advanced Formula Eye
- •Visine Red Eye Comfort
- •Eyes Irritation Relief
- •Rite Aid Multi-Symptom Relief Eye Drops
- •Signature Care Eye Drops A.C.
- •Good Neighbor Pharmacy Eye Drops Original Formula
- •Kroger Eye Drops Seasonal Relief
- •Topcare Health Ultra Itch Relief Astringent Eye Drops
- •Discount Drug Mart Eye Drops Original
- •Publix Advanced Relief Eye Drops
- •Equate Eye Drops
- •GoodSense Eye Drops Advanced Relief Moisturizer
- •Quality Choice Eye Drops Redness Relief
- •Rohto Ice
- •HEB Original Eye Drops
- •Medics Choice Eye Drops Advanced
- •Best Choice Eye Drops Original
- •Walgreens Multi-Symptom Relief Eye Drops
- •Foster and Thrive Original Formula Eye Drops
- •QC Sterile Red Eye
- •Signature Care Eye Drops Advanced Relief
- •Colirio Ocusan
- •Value Health by Prodose Eye Drops
- •Walgreens Eye Drops Original 15mL and twin pack
- •Quality Choice Eye Drops Irritation Relief
- •Code Red Eye Drops Redness Relief
- •Rohto All-In-One
- •TopCare Health Original Eye Drops
- •Meijer Redness Relief
- •Careall Redness Reliever Eye Drops
- •Family Wellness Advanced Redness Relief Eye Drops
- •Lil Drug Store Sterile Eye Drops Redness Reliever
- •Winco Advanced Relief Eye Drops
- •Winco Original Formula Eye Drops
- •CVS Multi-Symptom Eye Drops
- •Equate Original Eye Drops
- •Quality Choice Moisturizing Relief Eye Drops
- •Equaline Sterile Eye Drops
- •Good Neighbor Pharmacy Eye Drops Multi-Symptom Relief
- •GoodSense Eye Drops Irritation Relief
- •DG Original Eye Drops
- •Preferred Plus Pharmacy Redness Relief Eye Drops
- •Glitch Advanced Relief Eye Drops
- •Core Values Eye Drops Advanced Relief
- •Circle K sterile eye drops
- •CVS Astringent Eye
- •Meijer Multi-Symptom Relief
- •Original Redness Reliever
- •Kroger Eye Drops Original
- •HEB Advanced Eye Drops
- •Equaline Eye Drops A.C.
- •Discount Drug Mart Eye Drops Multi-Symptom Relief
- •Exchange Select Eye Drops Advanced Relief Moisturizer
- •Best Choice Eye Drops A.C.
- •Redness Reliever, Circle K
- •Harris Teeter Eye Drops Advanced Relief
- •Harris Teeter Eye Drops Original
- •CareOne Itchy Relief Eye Drops 15mL
- •Kroger Eye Drops Advanced Relief
- •Meijer Seasonal Itching and Redness Relief
- •Discount Drug Mart Eye Drops Advanced Relief
- •Family Wellness Original Redness Relief Eye Drops
- •Medics Choice Eye Drops Seasonal Relief
- •Best Choice Eye Drops Advanced Relief
- •Walgreens Eye Drops Seasonal Relief 15mL
- •Leader Advanced Relief Eye Drops
- •Meijer Advanced Redness and Irritation Relief
- •CVS Advanced Eye Drops
- •Discount Drug Mart Eye Drops A.C.
- •Visine Red Eye Hydrating Comfort, CVP
- •Winco Irritation Relief Eye
- •Walgreens Eye Drops Advanced Relief 15mL
- •Visine Red Eye Total Comfort Multi-Symptom
- •TopCare Health Advanced Moisturizing Plus Redness Relief
- •HEB A.C. Eye Drops
- •Advanced relief
- •Sunmark Eye Drops Original Formula
- •CVP Sterile Eye Drops
- •Multi-Action Relief
- •Lil Drug Store Eye Drops Redness Reliever
- •Clear Eyes Triple Relief
- •Visine A.C. Itchy Eye Relief
- •Foster and Thrive Advanced Relief Eye Drops
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Vendor Pricing
$2.01/gCombi-Blocks, Inc.
CountryUnited States
Pack$1005.00 / 500 g
Purity98%
Vendors26 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
25 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Aaron Chemicals LLC | Hong Kong | $2.06 | 500 g | 98% |
| A2B Chem LLC | United States | $2.21 | 100 g | 98% |
| BLD Pharmatech Ltd. | China | $2.30 | 500 g | 98% |
| Angene Chemical | China → Hong Kong | $2.36 | 500 g | 98% |
| AA BLOCKS | United States | $2.74 | 100 g | 98% |
| BLD Pharmatech Co., Limited | United States | $2.88 | 100 g | 98% |
| Ambeed, Inc. | United States | $2.88 | 100 g | 98% |
| BLD Pharmatech GmbH | Germany | $3.48 | 25 g | 98% |
| AK Scientific, Inc. | United States | $19.44 | 50 g | 98% |
| MedChemExpress MCE | Sweden | $19.96 | 10 g | 99.88% |
| AstaTech, Inc | United States | $23.20 | 10 g | 95% |
| TargetMol Chemicals | China → United States | $29.00 | 1 g | 99.97% |
| MedKoo Biosciences, Inc | United States | $33.00 | 50 g | 98% |
| Cayman Europe | Estonia | $36.13 | 50 g | 98% |
| Sigma-Aldrich (Rush Stock) | Germany | $53.65 | 10 g | 98% |
| Sigma-Aldrich | Germany | $53.65 | 10 g | 98% |
| Apexbio Technology LLC | United States | $58.00 | 1 g | 99.83% |
| Molnova | China | $74.00 | 500 mg | 99% |
| Angene International Limited | United States | $151.00 | 1 g | 99% |
| Labotest KG | Germany | $453.00 | 1000 mg | 90% |
| AK Scientific Specialized | United States | $710.00 | 100 mg | 99% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 98% |
| Key Organics Ltd. | United Kingdom | $6900.00 | 10 mg | 98% |
| TimTec, LLC | United States | $13333.33 | 30 mg | 90% |
| Interbioscreen | Hong Kong | $52900.00 | 1 mg | 95% |
Chemical Identity
CAS522-48-5
PubChem CID10648
DTXSIDDTXSID7045316
FormulaC13H17ClN2
Mol. Weight236.74 g/mol
SMILESC1CC(C2=CC=CC=C2C1)C3=NCCN3.Cl
Data Sources
- PubChem · compound 10648Retrieved 2026-04-07
- EPA TSCA InventoryRetrieved 2026-04-24
- FDA National Drug Code directoryRetrieved 2026-04-07
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Tetrahydrozoline hydrochloride (CAS 522-48-5) https://chemicalindependence.com/chemical/522-48-5/ PubChem: 10648. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/10648 EPA TSCA Inventory: CAS 522-48-5. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 522-48-5. Reporting year: 2024. https://usatrade.census.gov/