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Codeine phosphate

Drug ingredient

CAS 52-28-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 52-28-8
US productionNot reported
Import value, 2024$103M
Top sourceAustralia 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293911 · basket

These shares come from HS customs code 293911, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
AU 31%AustraliaGB 27%United KingdomCZ 19%Czech RepublicDE 14%GermanyES 5%Spain
46 FDA-registered drug labelers
A-S Medication Solutions
Actavis Pharma, Inc.
Advanced Rx of Tennessee, LLC
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals of New York, LLC
Aphena Pharma Solutions - Tennessee, LLC
Asclemed USA, Inc.
ATLANTIC BIOLOGICALS CORP.
Aurolife Pharma, LLC
Breckenridge Pharmaceutical, Inc.
Bryant Ranch Prepack
Cardinal Health 107, LLC
Chattem Chemicals, Inc.
Clinical Solutions Wholesale, LLC
Cosette Pharmaceuticals, Inc.
Cranbury Pharmaceuticals, LLC
Direct_Rx
Elite Laboratories, Inc.
Eywa Pharma Inc
Genus Lifesciences Inc.
Hikma Pharmaceuticals USA Inc.
LGM PHARMA SOLUTIONS, LLC
Llorens Pharmaceutical International Division
Mainpointe Pharmaceuticals
Marnel Pharmaceuticals, LLC
Medisca Inc.
Method Pharmaceuticals, LLC
Noramco, LLC
NuCare Pharmaceuticals, Inc.
PAI Holdings, LLC
PAI Holdings, LLC dba PAI Pharma
Poly Pharmaceuticals, Inc.
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
QUAGEN PHARMACEUTICALS LLC
Quality Care Products, LLC
RedPharm Drug, Inc.
REMEDYREPACK INC.
Siegfried USA, LLC
SpecGx LLC
ST. MARY'S MEDICAL PARK PHARMACY
Strides Pharma Science Limited
Veranova, L.P.
Westminster Pharmaceuticals, LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 14 drug and cosmetic product listings (FDA).

  • •Acetaminophen and Codeine Phosphate
  • •Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
  • •Acetaminophen and Codeine
  • •Promethazine and Phenylephrine HCl, and Codeine Phosphate
  • •Promethazine Hydrochloride and Codeine Phosphate
  • •Codeine-Guaifenesin
  • •Duratuss AC
  • •Ascomp with Codeine
Show all 14
  • •Guaifenesin and Codeine Phosphate
  • •Tusnel C
  • •Fioricet with Codeine
  • •Butalbital, Aspirin, Caffeine AND Codeine Phosphate
  • •Tuxarin
  • •MAR-COF CG Expectorant
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS52-28-8
PubChem CID5359227
DTXSIDDTXSID0024844
FormulaC18H24NO7P
Mol. Weight397.4 g/mol
SMILESCN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O.OP(=O)(O)O

Data Sources

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Brief citations

Codeine phosphate (CAS 52-28-8) https://chemicalindependence.com/chemical/52-28-8/ PubChem: 5359227. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5359227 FDA National Drug Code directory: CAS 52-28-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293911 for CAS 52-28-8. Reporting year: 2024. https://usatrade.census.gov/