Thiotepa

Drug ingredient

CAS 52-24-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.4B

Top sourceIreland 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293399 · basket

These shares come from HS customs code 293399, which covers 518 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 33%IrelandCN 26%ChinaIN 11%IndiaDE 9%GermanyIT 4%Italy

Taiwan
Poland
Canada
Ivory Coast
Greece
Hungary
Indonesia
Latvia
Belgium
Slovakia
Czech Republic
Austria
Netherlands
Finland
Denmark
Croatia
Australia
South Africa
Sweden
Hong Kong
Malta
Singapore
Lithuania
Malaysia
Oman
Serbia

15 FDA-registered drug labelers

American Pacific Corporation

Amneal Pharmaceuticals LLC

Dr.Reddy's Laboratories Inc.,

Fresenius Kabi USA, LLC

Gland Pharma Limited

Heraeus Precious Metals GmbH & Co. KG

Hikma Pharmaceuticals USA Inc.

Indena S.p.A

Meitheal Pharmaceuticals Inc

MSN Laboratories Private Limited

NATCO PHARMA LIMITED

Novadoz Pharmaceuticals LLC

Piramal Pharma Solutions Inc.

Sagent Pharmaceuticals

Shorla Oncology Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Thiotepa
•Tepylute
•Tepadina

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$184.00/gA2B Chem LLC

CountryUnited States

Pack$92.00 / 500 mg

Purity97%

Vendors18 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

17 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$204.00	500 mg	97%
Sigma-Aldrich (Rush Stock)	Germany	$277.39	1 g	102%
Sigma-Aldrich	Germany	$277.39	1 g	102%
Cayman Europe	Estonia	$290.36	500 mg	98%
Aaron Chemicals LLC	Hong Kong	$326.00	1 g	98%
Angene Chemical	China → Hong Kong	$356.00	1 g	98%
AstaTech (2 weeks)	United States	$361.00	1 g	98%
Labotest KG	Germany	$453.00	1000 mg	90%
Ambeed, Inc.	United States	$660.00	250 mg	97%
Molnova	China	$856.00	500 mg	99%
TargetMol Chemicals	China → United States	$950.00	500 mg	99.07%
MedKoo Biosciences, Inc	United States	$1250.00	1 g	98%
TargetMol Chemicals EU	Austria	$1890.00	100 mg	99.07%
Apexbio Technology LLC	United States	$2400.00	100 mg	98%
MedChemExpress MCE	Sweden	$2879.80	100 mg	99.98%
Angene International Limited	United States	$4760.00	25 mg	98%
Fulfilled by Molport	Latvia	$10000.00	1 mg	99.1%

Chemical Identity

CAS52-24-4

PubChem CID5453

DTXSIDDTXSID0021339

FormulaC6H12N3PS

Mol. Weight189.22 g/mol

SMILESC1CN1P(=S)(N2CC2)N3CC3

Data Sources

PubChem · compound 5453Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Thiotepa (CAS 52-24-4) https://chemicalindependence.com/chemical/52-24-4/ PubChem: 5453. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5453 FDA National Drug Code directory: CAS 52-24-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293399 for CAS 52-24-4. Reporting year: 2024. https://usatrade.census.gov/