Spironolactone

Drug ingredient

CAS 52-01-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 52-01-7
US productionNot reported
Import value, 2024$286M
Top sourceChina 48%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293220 · basket

These shares come from HS customs code 293220, which covers 151 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 48%ChinaIN 15%IndiaJP 7%JapanGB 7%United KingdomCH 7%Switzerland
54 FDA-registered drug labelers
A-S Medication Solutions
Accord Healthcare, Inc.
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals NY LLC
Amneal Pharmaceuticals of New York LLC
Aphena Pharma Solutions - Tennessee, LLC
Asclemed USA, Inc.
ATLANTIC BIOLOGICALS CORP.
Aurobindo Pharma Limited
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Cardinal Health 107, LLC
CMP Pharma, Inc.
Coupler LLC
Dasami Lab Private Limited
Direct_Rx
EUROAPI FRANCE
Galenova Inc
Gedeon Richter Plc.
Guna spa
Henan Lihua Pharmaceutical Co Ltd
Jubilant Cadista Pharmacuticals Inc.
LETCO MEDICAL, LLC
Major Pharmaceuticals
Medisca Inc.
Mylan Institutional Inc.
Mylan Pharmaceuticals Inc.
NCS HealthCare of KY, LLC dba Vangard Labs
NorthStar Rx LLC
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
Oxford Pharmaceuticals, LLC
Padagis US LLC
PD-Rx Pharmaceuticals, Inc.
Pfizer Laboratories Div Pfizer Inc
Pharma Source Direct, Inc.
PharmPak, Inc.
Piramal Healthcare UK Limited
Prasco Laboratories
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
QPharma, Inc.
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Spectrum Laboratory Products, Inc.
Sun Pharmaceutical Industries, Inc.
Tianjin Jinjin Pharmaceutical Co.,Ltd
Tianjin Tianyao Pharmaceuticals Co., Ltd.
Zhejiang Langhua Pharmaceutical Co. Ltd.
Zhejiang Shenzhou Pharmaceutical Co., Ltd.
Zydus Lifesciences Limited
Zydus Pharmaceuticals (USA) Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

  • •Spironolactone
  • •Spironolactone and Hydrochlorothiazide
  • •CaroSpir
  • •Aldactone
  • •GUNA-DIUR
FDA Shortage Status
No Shortage
Shortage History
  • to be discontinued

    Spironolactone Tablet

    Shortage listed since December 10, 2025

See all current drug shortages

Vendor Pricing

$10.04/gA2B Chem LLC
CountryUnited States
Pack$1004.00 / 100 g
Purity97%
Vendors22 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS52-01-7
PubChem CID5833
DTXSIDDTXSID6034186
FormulaC24H32O4S
Mol. Weight416.6 g/mol
SMILESCC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C

Data Sources

Brief citations

Spironolactone (CAS 52-01-7) https://chemicalindependence.com/chemical/52-01-7/ PubChem: 5833. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5833 EPA TSCA Inventory: CAS 52-01-7. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 52-01-7. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293220 for CAS 52-01-7. Reporting year: 2024. https://usatrade.census.gov/