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Norethindrone acetate

Drug ingredient

CAS 51-98-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 51-98-9
US productionNot reported
Import value, 2024$76M
Top sourceSpain 35%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293723 · basket

These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary
32 FDA-registered drug labelers
A-S Medication Solutions
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals NY LLC
Aspen Oss B.V.
Aurobindo Pharma Limited
AvKARE
Bayer AG
Breckenridge Pharmaceutical, Inc.
Brichem Sciences Private Limited
Catalent Pharma Solutions, LLC
Direct_Rx
Douglas Manufacturing Limited
Glenmark Pharmaceuticals Inc., USA
Golden State Medical Supply, Inc.
Ingenus Pharmaceuticals, LLC
Lupin Pharmaceuticals, Inc.
Mylan Pharmaceuticals Inc.
Naari Pte. Limited
NextPharma Ploermel
Nivagen Pharmaceuticals, Inc.
Noven Therapeutics, LLC
Patheon Inc.
Patheon Softgels Inc.
Proficient Rx LP
SCH Global Services Private Limited
STERLING SPA
Sumitomo Pharma America, Inc
Teva Pharmaceuticals USA, Inc.
Teva Women's Health LLC
Valdepharm
Xiromed LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 23 drug and cosmetic product listings (FDA).

  • •Estradiol AND Norethindrone Acetate
  • •Norethindrone Acetate
  • •Junel 21 Day
  • •Fyavolv
  • •Norethindrone Acetate AND Ethinyl Estradiol
  • •Jinteli
  • •Abigale LO
  • •Luizza 1/20
Show all 23
  • •Junel FE
  • •Mimvey
  • •Loestrin 21 Day
  • •Estradiol / Norethindrone Acetate
  • •Etyqa
  • •Hailey 1.5/30
  • •Activella
  • •Aurovela 1/20
  • •Lopreeza
  • •CombiPatch (estradiol/norethindrone acetate transdermal system)
  • •Abigale
  • •Luizza 1.5/30
  • •Aurovela 1.5/30
  • •Gallifrey
  • •Myfembree
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS51-98-9
PubChem CID5832
DTXSIDDTXSID4023381
FormulaC22H28O3
Mol. Weight340.5 g/mol
SMILESCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C)C#C

Data Sources

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Brief citations

Norethindrone acetate (CAS 51-98-9) https://chemicalindependence.com/chemical/51-98-9/ PubChem: 5832. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5832 FDA National Drug Code directory: CAS 51-98-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293723 for CAS 51-98-9. Reporting year: 2024. https://usatrade.census.gov/