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Neostigmine methylsulfate

Drug ingredient

CAS 51-60-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 51-60-5
US productionNot reported
Import value, 2024$872M
Top sourceSwitzerland 44%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292429 · basket

These shares come from HS customs code 292429, which covers 203 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CH 44%SwitzerlandCN 19%ChinaIN 12%IndiaJP 9%JapanIE 6%Ireland
32 FDA-registered drug labelers
Amneal Pharmaceuticals LLC
Amphastar Pharmaceuticals, Inc.
Aurobindo Pharma Limited
BE Pharmaceuticals Inc.
Camber Pharmaceuticals Inc.
Caplin Steriles Limited
Civica, Inc.
Dr.Reddy's Laboratories Inc
Emcure Pharmaceuticals Limited
Enaltec Labs Pvt Ltd
Endo USA
Eugia US LLC
Exela Pharma Sciences, LLC
Fresenius Kabi USA, LLC
Gland Pharma Limited
Harman Finochem Limited
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
HF Acquisition Co LLC, DBA HealthFirst
Hikma Pharmaceuticals USA Inc.
Hubei Haosun Pharmaceutical Co., Ltd.
Indoco Remedies Limited
Medical Purchasing Solutions, LLC
MEDISCA Inc.
Meitheal Pharmaceuticals Inc.
MSN Laboratories Private Limited
Par Health USA, LLC
Patheon Austria GmbH & CoKG
ProPharma Distribution
Sagent Pharmaceuticals
Somerset Therapeutics, LLC
Xellia Pharmaceuticals USA LLC
Xiromed LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

  • •Neostigmine Methylsulfate
  • •Neostigmine
  • •Prevduo
  • •Bloxiverz
FDA Shortage Status
No Shortage
Shortage History
  • to be discontinued

    Neostigmine Methylsulfate Injection

    Shortage listed since January 12, 2026

See all current drug shortages

Vendor Pricing

$7.44/gA2B Chem LLC
CountryUnited States
Pack$186.00 / 25 g
Purity99.53%
Vendors21 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

20 more vendors
VendorCountry$/gPackPurity
AA BLOCKSUnited States$7.9625 g98%
Aaron Chemicals LLCHong Kong$9.1625 g98%
Angene ChemicalChina → Hong Kong$9.8425 g98%
AK Scientific SpecializedUnited States$11.0425 g95%
AK Scientific, Inc.United States$16.4025 g98%
Sigma-Aldrich (Rush Stock)Germany$48.945 g—
Sigma-AldrichGermany$48.945 g—
Ambeed, Inc.United States$80.00250 mg98%
Cayman EuropeEstonia$86.871 g98%
Fulfilled by MolportLatvia$90.00100 mg98%
MedKoo Biosciences, IncUnited States$125.0010 g98%
TargetMol ChemicalsChina → United States$138.001 g99.9%
TargetMol Chemicals EUAustria$190.00500 mg99.9%
MolnovaChina$270.00200 mg99%
AstaTech (2 weeks)United States$351.605 g98%
Labotest KGGermany$453.001000 mg90%
MedChemExpress MCESweden$750.20100 mg99.5%
Axon MedchemNetherlands$960.0050 mg100%
Angene International LimitedUnited States$1130.00100 mg98%
AngeneChina → Hong Kong$4266.6730 mg98%

Chemical Identity

CAS51-60-5
PubChem CID5824
DTXSIDDTXSID40199003
FormulaC13H22N2O6S
Mol. Weight334.39 g/mol
SMILESCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.COS(=O)(=O)[O-]

Data Sources

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Brief citations

Neostigmine methylsulfate (CAS 51-60-5) https://chemicalindependence.com/chemical/51-60-5/ PubChem: 5824. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5824 FDA National Drug Code directory: CAS 51-60-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 51-60-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 292429 for CAS 51-60-5. Reporting year: 2024. https://usatrade.census.gov/