Histamine

Drug ingredient

CAS 51-45-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 51-45-6
US productionNot reported
Import value, 2024$114M
Top sourceChina 26%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293329 · basket

These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy
5 FDA-registered drug labelers
Energetix Corporation
Homeocare Laboratories
Jubilant HollisterStier LLC
Meditrend, Inc. DBA Progena Professional Formulations
Professional Complementary Health Formulas

Why It Matters

Sectors
Health
Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

  • •Allergena Pet Dander
  • •Allergy Nosode 4017
  • •Breathe-Ease
  • •Isopathic Phenolic Rings
  • •Positive Skin Test Control - Histamine
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$11.18/gAngene Chemical
CountryChina (registered: Hong Kong)
Pack$1118.00 / 100 g
Purity98%
Vendors17 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS51-45-6
PubChem CID774
DTXSIDDTXSID4023125
FormulaC5H9N3
Mol. Weight111.15 g/mol
SMILESC1=C(NC=N1)CCN

Data Sources

Brief citations

Histamine (CAS 51-45-6) https://chemicalindependence.com/chemical/51-45-6/ PubChem: 774. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/774 EPA TSCA Inventory: CAS 51-45-6. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 51-45-6. Reporting year: 2024. https://usatrade.census.gov/