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Epinephrine bitartrate

Drug ingredientActive Shortage

CAS 51-42-3

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 51-42-3
US productionNot reported
Import value, 2024$174M
Top sourceItaly 69%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293790 · basket

These shares come from HS customs code 293790, which covers 10 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IT 69%ItalyCN 22%ChinaDE 3%GermanyIN 2%IndiaJP 2%Japan
35 FDA-registered drug labelers
A-S Medication Solutions
B. Braun Medical Inc.
Baxter Healthcare Corporation
Benco Dental
Burkhart Dental Supply Co., Inc
Cambrex Profarmaco Milano Srl
Darby Dental Supply, LLC
Dentsply Pharmaceutical
Dentsply Pharmaceutical Inc.
Fagron Essentials, LLC
Fresenius Kabi USA, LLC
hameln rds s.r.o.
Harman Finochem Limited
Henry Schein
Henry Schein Inc.
HF Acquisition Co LLC, DBA HealthFirst
Hospira, Inc.
LETCO MEDICAL, LLC
Mylan Laboratories Limited
NDC, Inc.
Novocol Pharmaceutical of Canada, Inc.
Patterson Dental
Pierrel S.p.A.
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
ProPharma Distribution
REMEDYREPACK INC.
Safco Dental Supply Co
Septodont Inc.
Spectrum Laboratory Products, Inc.
Sportpharm LLC
Syn-Tech Chem. & Pharm. Co. LTD.
The Atlanta Dental Supply Company DBA Advanced Dental Products
Viyash Life Sciences Private Limited
Wuhan Wuyao Pharmaceutical Co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 28 drug and cosmetic product listings (FDA).

  • •Marcaine with Epinephrine
  • •Orabloc
  • •Articaine
  • •Citanest Forte Dental
  • •Lidocaine HCI AND Epinephrine
  • •Xylocaine
  • •Xylocaine MPF
  • •Lignospan Forte
Show all 28
  • •Septocaine and Epinephrine
  • •Bupivacaine Hydrochloride and Epinephrine
  • •Articaine Hydrochloride and Epinephrine
  • •Lidocaine HCl and Epinephrine
  • •Flavalta
  • •Lidocaine
  • •Bupivacaine HCI AND Epinephrine
  • •Vivacaine
  • •Sensorcaine
  • •epinephrine
  • •Lignospan Standard
  • •Sensorcaine(R) (Bupivacaine HCI AND Epinephrine)
  • •Sensorcaine MPF
  • •Zorcaine
  • •Lidocaine HCI AND Epinephrine WITH Epinephrine
  • •Articaine HCl and Epinephrine
  • •Xylocaine-MPF WITH EPI
  • •Articadent
  • •Marcaine
  • •Xylocaine(R) -MPF (Lidocaine HCI AND Epinephrine)
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Epinephrine Bitartrate, Lidocaine Hydrochloride Injection

    Shortage listed since February 22, 2012

    Manufacturer reports: 1 unavailable, 1 limited, 2 available

  • Current shortage

    Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection

    Shortage listed since February 20, 2018

    Manufacturer reports: 1 unavailable, 1 available

See all current drug shortages

Chemical Identity

CAS51-42-3
PubChem CID5815
DTXSIDDTXSID3049415
FormulaC13H19NO9
Mol. Weight333.29 g/mol
SMILESCNCC(C1=CC(=C(C=C1)O)O)O.C(C(C(=O)O)O)(C(=O)O)O

Data Sources

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Brief citations

Epinephrine bitartrate (CAS 51-42-3) https://chemicalindependence.com/chemical/51-42-3/ PubChem: 5815. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5815 FDA National Drug Code directory: CAS 51-42-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 51-42-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293790 for CAS 51-42-3. Reporting year: 2024. https://usatrade.census.gov/