Piperonyl butoxide

Drug ingredient

CAS 51-03-6

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$3.5B

Import volumeZero

Top sourceIreland 57%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293299 · basket

EPA reports by year

2023: US production Confidential · Imports Zero
2019: US production Confidential · Imports Zero

These shares come from HS customs code 293299, which covers 229 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 57%IrelandNL 24%NetherlandsCH 8%SwitzerlandCN 5%ChinaIT 2%Italy

United Kingdom
Japan
Germany
Spain
Israel
Canada
Brazil
Vietnam
Ukraine
New Zealand
Belgium
Mexico
Singapore
Taiwan
South Korea
Sweden
South Africa
Egypt
Indonesia
Lithuania
Finland
Hungary
Czech Republic
Hong Kong
Malaysia
Slovakia
Australia
Russia
Jordan
Latvia
Argentina
Slovenia
Malta
Poland
Denmark
Austria

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Santolubes

28 FDA-registered drug labelers

AmerisourceBergen Drug Corporation

CVS

Discount Drug Mart

DLC Laboratories

DLC laboratories Inc.

Endura Spa

Family Dollar

GM Pharmaceuticals, INC

GRANDALL DISTRIBUTING, LLC

LEADER/ Cardinal Health 110, Inc.

Major Pharmaceuticals

MarcasUSA LLC

MarcusUSA

McLaughlin Gormley King Company

Meijer, Inc.

Menper Distributors Inc.

Oystershell Consumer Health Inc

Perrigo Direct, Inc.

PHARMACY VALUE ALLIANCE LLC

Pharmadel

Quality Choice

Rite Aid Corp

Strategic Sourcing Services, LLC

The Kroger Co

Topco Associates, LLC

Valu Merchandisers, CO.

Walgreens CO

Weeks & Leo Co., Inc

Why It Matters

Sectors

HealthAgriculture

Downstream Uses

Appears in 27 drug and cosmetic product listings (FDA).

•Herklin
•Meijer Lice Killing
•GoodSense Lice Killing
•Vanalice
•CVS Health Lice Killing
•Major Lice Killing
•Lice Killing
•Herklin Lice Treatment

Show all 27

•RID Lice Killing
•Kroger Lice Killing
•El Piojito Lice Killing
•Quality Choice Lice Killing
•Discount Drug Mart Lice Killing
•ABC Lice Killing
•Liendrex
•Leader Lice Killing
•Foster and Thrive Lice Killing
•Family Wellness Lice Killing
•Lice No More Lice Killing
•Walgreens Lice Killing
•Rite Aid Lice Killing
•Quita Piojos Lice Killing
•Best Choice Lice Killing
•Topcare Lice Killing
•ZAP Lice Killing
•GNP Lice Killing
•Mata Piojos Lice

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$0.09/gAaron Chemicals LLC

CountryHong Kong

Pack$46.00 / 500 g

Purity95%

Vendors22 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

21 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.11	500 g	95%
BLD Pharmatech GmbH	Germany	$0.13	1 kg	95%
BLD Pharmatech Ltd.	China	$0.13	1 kg	95%
A2B Chem LLC	United States	$0.13	500 g	95%
AstaTech, Inc	United States	$0.14	500 g	95%
Ambeed, Inc.	United States	$0.14	1 kg	95%
AK Scientific Specialized	United States	$0.14	1 kg	90%
AA BLOCKS	United States	$0.14	500 g	95%
BLD Pharmatech Co., Limited	United States	$0.18	500 g	95%
AK Scientific, Inc.	United States	$0.38	500 g	95%
Angene International Limited	United States	$0.66	500 g	95%
TargetMol Chemicals	China → United States	$93.00	1 g	99.84%
MedChemExpress MCE	Sweden	$200.86	500 mg	98%
Molnova	China	$305.00	200 mg	99%
Sigma-Aldrich (Rush Stock)	Germany	$831.10	100 mg	—
Sigma-Aldrich	Germany	$831.10	100 mg	—
Cayman Europe	Estonia	$1332.80	100 mg	95%
Angene	China → Hong Kong	$4266.67	30 mg	95%
MedKoo Biosciences, Inc	United States	$5600.00	100 mg	98%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	95%
TimTec, LLC	United States	$9333.33	30 mg	90%

Chemical Identity

CAS51-03-6

PubChem CID5794

DTXSIDDTXSID1021166

FormulaC19H30O5

Mol. Weight338.4 g/mol

SMILESCCCCOCCOCCOCC1=CC2=C(C=C1CCC)OCO2

Data Sources

EPA CompTox (DSSTox) · DTXSID1021166Retrieved 2026-04-06
PubChem · compound 5794Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Piperonyl butoxide (CAS 51-03-6) https://chemicalindependence.com/chemical/51-03-6/ EPA CompTox (DSSTox): DTXSID1021166. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166 PubChem: 5794. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/5794 EPA Chemical Data Reporting: 51-03-6. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 51-03-6. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293299 for CAS 51-03-6. Reporting year: 2024. https://usatrade.census.gov/