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Rilpivirine

Drug ingredient

CAS 500287-72-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 500287-72-9
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
6 FDA-registered drug labelers
Cipla Ltd.
Delmar Chemicals Inc
Janssen Pharmaceutica, NV
Minakem Beuvry Production
MSN Pharmachem Private Limited
Synergy Health AST, LLC

Why It Matters

Sectors
Health
Downstream UsesNot recorded
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS500287-72-9
PubChem CID6451164
DTXSIDDTXSID10198189
FormulaC22H18N6
Mol. Weight366.4 g/mol
SMILESCC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)C=CC#N

Data Sources

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Brief citations

Rilpivirine (CAS 500287-72-9) https://chemicalindependence.com/chemical/500287-72-9/ PubChem: 6451164. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6451164 FDA National Drug Code directory: CAS 500287-72-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 500287-72-9. Reporting year: 2024. https://usatrade.census.gov/