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Estradiol benzoate

Drug ingredient

CAS 50-50-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 50-50-0
US productionNot reported
Import value, 2024$76M
Top sourceSpain 35%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293723 · basket

These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary
5 FDA-registered drug labelers
Bayer AG
Elanco US Inc.
Professional Complementary Health Formulas
Valdepharm
zhejiang xianju pharmaceutical co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Solvent/Small Ring Combination 9317
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS50-50-0
PubChem CID222757
DTXSIDDTXSID9022998
FormulaC25H28O3
Mol. Weight376.5 g/mol
SMILESCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)C5=CC=CC=C5

Data Sources

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Brief citations

Estradiol benzoate (CAS 50-50-0) https://chemicalindependence.com/chemical/50-50-0/ PubChem: 222757. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/222757 FDA National Drug Code directory: CAS 50-50-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293723 for CAS 50-50-0. Reporting year: 2024. https://usatrade.census.gov/