clomiphene citrate

Drug ingredient

CAS 50-41-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$197M

Top sourceChina 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292219 · basket

These shares come from HS customs code 292219, which covers 167 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 36%ChinaIT 15%ItalyDE 14%GermanyIN 7%IndiaHU 5%Hungary

Saudi Arabia
Lithuania
Canada
Ukraine
Israel
Singapore
Mexico
Ireland
Netherlands
Malaysia
Slovakia
Denmark
Finland
Latvia
Greece
Austria

26 FDA-registered drug labelers

A-S Medication Solutions

Accord Healthcare Inc.

Advagen Pharma Ltd

ALMON HEALTHCARE PRIVATE LIMITED

ANI Pharmaceuticals, Inc.

Appco Pharma LLC

ASG Biochem Private Limited

AX Pharmaceutical Corp

Bills Biotech Private Limited

Burel Pharmaceuticals, LLC

Cosette Pharmaceuticals NC Laboratories, LLC

Cosette Pharmaceuticals, Inc.

DARMERICA, LLC

Excella GmbH & Co. KG

F.I.S. FABBRICA ITALIANA SINTETICI SPA

Fagron Inc

LETCO MEDICAL, LLC

Medisca Inc.

Menadiona, S.L.

PCAS

Pharma Source Direct, Inc.

Qingdao Biopeptek Co., Ltd.

Qingdao Qinzeyuan Biotechnology Co., Ltd

RISING PHARMA HOLDINGS, INC.

SCH Global Services Private Limited

Viyash Life Sciences Private Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Clomid
•Clomiphene Citrate
•MiloPhene

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS50-41-9

PubChem CID60974

DTXSIDDTXSID8020337

FormulaC32H36ClNO8

Mol. Weight598.1 g/mol

SMILESCCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Data Sources

PubChem · compound 60974Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

clomiphene citrate (CAS 50-41-9) https://chemicalindependence.com/chemical/50-41-9/ PubChem: 60974. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/60974 FDA National Drug Code directory: CAS 50-41-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292219 for CAS 50-41-9. Reporting year: 2024. https://usatrade.census.gov/