estradiol
Drug ingredientCAS 50-28-2
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Import value, 2024$76M
Top sourceSpain 35%
This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293723 · basket
These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary
- Canada
- United Kingdom
- Taiwan
74 FDA-registered drug labelers
A-S Medication Solutions
Allergan, Inc.
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals NY LLC
Amneal Pharmaceuticals of New York LLC
ANI Pharmaceuticals, Inc.
ASCEND Therapeutics US, LLC
Asclemed USA, Inc.
Aspen Oss B.V.
Aurobindo Pharma Limited
AvKARE
Bayer HealthCare Pharmaceuticals Inc.
BioActive Nutritional, Inc.
Breckenridge Pharmaceutical, Inc.
Bryant Ranch Prepack
Catalent Micron Technologies Ltd
Catalent Pharma Solutions LLC
Coupler LLC
Cutyx Research LLP
Deseret Biologicals
Deseret Biologicals, Inc.
Direct_Rx
DMD Clinical Naturopathy
Dr. Donna Restivo DC
Encube Ethicals, Inc.
Energique, Inc.
EPIC PHARMA, LLC
Gedeon Richter Plc.
Glenmark Pharmaceuticals Inc., USA
Guna spa
Hengyang Chuangjiujia Trading Co., Ltd.
Hubei Gedian humanwell Pharmaceutical Co., Ltd
Ingenus Pharmaceuticals, LLC
LETCO MEDICAL, LLC
Mayne Pharma
Mayne Pharma LLC
MEDISCA Inc.
Mylan Pharmaceuticals Inc.
Naari Pte. Limited
NorthStar Rx LLC
Northwind Health Company, LLC
Noven Therapeutics, LLC
Novo Nordisk
NuCare Pharmaceuticals, Inc.
Nutrition Unlimited INC
Nutritional Specialties, Inc.
Orion Corporation, Orion Pharma
Padagis Israel Pharmaceuticals Ltd
Padagis US LLC
PD-Rx Pharmaceuticals, Inc.
Pfizer Laboratories Div Pfizer Inc
PharmPak, Inc.
Prasco Laboratories
Preferred Pharmaceuticals Inc.
ProBLEN
Professional Complementary Health Formulas
Proficient Rx LP
PURACAP LABORATORIES, LLC
Qinhuangdao Zizhu Pharmaceutical Co., Ltd.
REMEDYREPACK INC.
Sandoz Inc
SHAKTI LIFESCIENCE PRIVATE LIMITED
SHYNE BRANDS
SHYNE BRANDS/BIOLabs PRO
Solaris Pharma Corporation
Spectrum Laboratory Products, Inc.
Teva Pharmaceuticals USA, Inc.
Trigen Laboratories, LLC
Vertical Pharmaceuticals, LLC
Viatris Specialty LLC
Xiromed LLC
Zydus Lifesciences Limited
Zydus Pharmaceuticals USA Inc.
Why It Matters
Sectors
Health
Downstream Uses
Appears in 60 drug and cosmetic product listings (FDA).
- •Estradiol
- •Estradiol AND Norethindrone Acetate
- •Balance Plus Cream
- •3.6oz BiEST 2.5 Estrogen Cream
- •Estriol cream
- •Estradiol Transdermal System
- •Estradiol Gel
- •EstroPRO Homeopathic Organotherapy
Show all 60
- •Strength F
- •Climara
- •Menostar
- •Young Again
- •Dotti
- •Vivelle-Dot
- •Estradiol Vaginal
- •Imvexxy
- •Female Stimulant
- •Immune Forte
- •Estrogens
- •Estradiol 1557
- •Lyllana
- •Estradiol Vaginal Cream
- •Divigel
- •Estradiol Vaginal Inserts
- •Minivelle
- •Female Liquescence
- •Dr Dale Wellness NU Fem 1 2 3 All In One Topical Homeopathic
- •Yuvafem
- •HGH Vitality
- •High Vitality Tab
- •Gynobalance
- •Angeliq
- •Bijuva
- •Abigale LO
- •Evamist
- •Mimvey
- •Estradiol / Norethindrone Acetate
- •Etyqa
- •Prostate Liquescence
- •HelloPharmacist Bi-EST 5.0 Cream
- •Activella
- •Lopreeza
- •Estrace
- •BiEST 5.0 Estrogen Cream - 3.6oz
- •Vagifem
- •High Vitality
- •Climara Pro
- •Estrogen and Progesterone
- •Lipotox
- •Estrogen Phenolic
- •Multi-Phenolic
- •CombiPatch (estradiol/norethindrone acetate transdermal system)
- •Abigale
- •Estrogen 4X
- •Histamine Balancer
- •GUNA-PMS
- •EstroGel
- •BiEST 5.0 Estrogen Cream
- •Estring
- •Elestrin
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No Shortage
Shortage History
Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.
- to be discontinued
Drospirenone; Ethinyl Estradiol Tablet
Shortage listed since May 2, 2025
- to be discontinued
Ethinyl Estradiol; Etonogestrel Ring
Shortage listed since June 16, 2025
- to be discontinued
Ethinyl Estradiol; Ethinyl Diacetate Tablet
Shortage listed since June 13, 2025
Vendor Pricing
$1.83/gAaron Chemicals LLC
CountryHong Kong
Pack$916.00 / 500 g
Purity98%
Vendors39 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
38 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Angene Chemical | China → Hong Kong | $1.84 | 500 g | 98% |
| AA BLOCKS | United States | $2.27 | 100 g | 99% |
| A2B Chem LLC | United States | $2.27 | 100 g | 99% |
| Chemscene | United States | $3.25 | 100 g | — |
| Fluorochem EU | Germany | $4.36 | 10 g | 97% |
| Angene International Limited | United States | $4.90 | 10 g | 97% |
| Fulfilled by Molport | Latvia | $5.00 | 1 g | 98% |
| Fluorochem UK | United Kingdom | $5.15 | 5 g | 97% |
| AstaTech, Inc | United States | $6.72 | 25 g | 97% |
| AK Scientific Specialized | United States | $14.20 | 5 g | 98% |
| Accela ChemBio | United States | $15.00 | 1 g | 97% |
| Cayman Europe | Estonia | $26.18 | 10 g | 98% |
| AK Scientific, Inc. | United States | $26.40 | 5 g | 97% |
| TargetMol Chemicals | China → United States | $37.50 | 2 g | 99.99% |
| Sigma-Aldrich (Rush Stock) | Germany | $51.90 | 100 g | — |
| Sigma-Aldrich | Germany | $51.90 | 100 g | — |
| Apexbio Technology LLC | United States | $57.00 | 1 g | 99.28% |
| Interbioscreen | Hong Kong | $64.50 | 10 g | 95% |
| Molnova | China | $82.00 | 500 mg | 99% |
| MedChemExpress MCE | Sweden | $82.28 | 1 g | 99.93% |
| MedKoo Biosciences, Inc | United States | $85.00 | 10 g | 98% |
| TargetMol Chemicals EU | Austria | $88.00 | 500 mg | 99.99% |
| Eximed | Ukraine | $160.00 | 1 g | 95% |
| A2B Chem LLC (1 week) | United States | $269.00 | 1 g | 99% |
| AA BLOCKS (1 week) | United States | $280.00 | 1 g | 99% |
| Biopharma PEG Scientific Inc. | United States | $288.00 | 1 g | 95% |
| Otava, Ltd. | Ukraine | $300.00 | 1 g | 90% |
| CliniSciences GmbH | Switzerland | $361.20 | 100 mg | 99% |
| ChemNorm | China | $440.00 | 100 mg | 98% |
| Labotest KG | Germany | $453.00 | 1000 mg | 90% |
| AstaTech (2 weeks) | United States | $470.00 | 1 g | 95% |
| Axon Medchem | Netherlands | $1320.00 | 100 mg | 99% |
| ChemFaces | China | $1500.00 | 20 mg | 98% |
| Specs | Netherlands | $1502.82 | 1 g | 90% |
| Otava, Ltd. (2 weeks) | Ukraine | $2724.00 | 50 mg | 90% |
| Princeton BioMolecular Research (SC) | United States | $2900.00 | 100 mg | 90% |
| Vitas M Chemical Limited | Hong Kong | $3170.00 | 100 mg | 90% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 98% |
Chemical Identity
CAS50-28-2
PubChem CID5757
DTXSIDDTXSID0020573
FormulaC18H24O2
Mol. Weight272.4 g/mol
SMILESCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
Data Sources
- PubChem · compound 5757Retrieved 2026-04-07
- FDA National Drug Code directoryRetrieved 2026-04-25
- FDA Drug ShortagesRetrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
estradiol (CAS 50-28-2) https://chemicalindependence.com/chemical/50-28-2/ PubChem: 5757. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5757 FDA National Drug Code directory: CAS 50-28-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 50-28-2. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293723 for CAS 50-28-2. Reporting year: 2024. https://usatrade.census.gov/