Flag of the United StatesAmerican Chemical Independence

Estriol

Drug ingredient

CAS 50-27-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 50-27-1
US productionNot reported
Import value, 2024$76M
Top sourceSpain 35%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293723 · basket

These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary
29 FDA-registered drug labelers
Asclemed USA, Inc.
ASG Biochem Pvt. LTD
Aspen Oss B.V.
AX Pharmaceutical Corp
Beijing JUNGE Technology Co., Ltd.
DARMERICA, LLC
Evereen Shanghai Biotechnology Ltd.
FOUNDATION COMMERCE INC
GLOWVERA
Guangxi Keyun E-commerce Co., Ltd.
Guangzhou Huixue Biotechnology Co., Ltd.
Hapila GmbH
Hengyang Chuangjiujia Trading Co., Ltd.
Hubei Redrui Building Materials Co., Ltd.
Jiangxi Yudexi Pharmaceutical Co., LTD
Jiashen International Trade Limited
LETCO MEDICAL, LLC
Medisca Inc.
Nutrition Unlimited INC
Pharma Source Direct, Inc.
ProBLEN
Professional Compounding Centers of America
Qinhuangdao Zizhu Pharmaceutical Co., Ltd.
Shenzhen Ishan Technology Co., Ltd
Shenzhen Mengyue Technology Co., Ltd.
SHYNE BRANDS
SHYNE BRANDS/BIOLabs PRO
Spectrum Laboratory Products, Inc.
zhejiang xianju pharmaceutical co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 22 drug and cosmetic product listings (FDA).

  • •Balance Plus Cream
  • •3.6oz BiEST 2.5 Estrogen Cream
  • •Estriol cream
  • •Myever
  • •EstroPRO Homeopathic Organotherapy
  • •Arthcal Estriol Face Cream for Women
  • •Arthcal Estrogen
  • •Estriol
Show all 22
  • •Vigority Estriol Cream
  • •HelloPharmacist Bi-EST 5.0 Cream
  • •Estriol 5.0 Cream
  • •BiEST 5.0 Estrogen Cream - 3.6oz
  • •Flocean Intimate Comfort
  • •DVO Estriol cream
  • •Estrogen and Progesterone
  • •Jovynex Women Estriol
  • •BiEST 5.0 Estrogen Cream
  • •Bunuss Estriol Face
  • •Beilloso Women Estriol
  • •Jardient
  • •Jardient Estriol Cream
  • •Lmnoop Feminine Cream
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$72.00/gTargetMol Chemicals
CountryChina (registered: United States)
Pack$72.00 / 1 g
Purity99.27%
Vendors7 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

6 more vendors
VendorCountry$/gPackPurity
TargetMol Chemicals USUnited States$100.00500 mg99.27%
AK Scientific, Inc.United States$130.001 g98%
AK Scientific SpecializedUnited States$182.001 g99%
Labotest KGGermany$453.001000 mg90%
Sigma-Aldrich (Rush Stock)Germany$4160.90100 mg93%
Sigma-AldrichGermany$4160.90100 mg93%

Chemical Identity

CAS50-27-1
PubChem CID5756
DTXSIDDTXSID9022366
FormulaC18H24O3
Mol. Weight288.4 g/mol
SMILESCC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O

Data Sources

← Back to Dashboard← Back to Health

Brief citations

Estriol (CAS 50-27-1) https://chemicalindependence.com/chemical/50-27-1/ PubChem: 5756. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5756 FDA National Drug Code directory: CAS 50-27-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293723 for CAS 50-27-1. Reporting year: 2024. https://usatrade.census.gov/