Phenobarbital

Drug ingredient

CAS 50-06-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6M

Top sourceBelgium 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293353 · basket

These shares come from HS customs code 293353, which covers 10 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

BE 33%BelgiumIN 21%IndiaHU 20%HungaryCN 14%ChinaDE 13%Germany

40 FDA-registered drug labelers

Advanz Pharma (US) Corp.

Ajenat Pharmaceuticals LLC

ALKALOIDA chemical company Zrt

American Health Packaging

ATLANTIC BIOLOGICALS CORP.

BPI Labs LLC

Bryant Ranch Prepack

Chartwell Governmental & Specialty RX, LLC.

Chartwell RX, LLC

Chemische Fabrik Berg GmbH

Clinical Solutions Wholesale, LLC

Coupler LLC

e5 Pharma, LLC

Endo USA, Inc.

Fagron Inc

Genus Lifesciences

Harman Finochem Limited

Hikma Pharmaceuticals USA Inc.

Ingenus Pharmaceuticals, LLC

J P N PHARMA PRIVATE LIMITED

KALINTIS HEALTHCARE PRIVATE LIMITED

Kesin Pharma Corporation

Major Pharmaceuticals

Medisca Inc.

Nantong Jinghua Pharmaceutical Co., Ltd.

PAI Holdings, LLC dba PAI Pharma

Pharmaceutical Associates, Inc.

Professional Compounding Centers of America dba PCCA

Proficient Rx LP

QUAGEN PHARMACEUTICALS LLC

Redpharm Drug

REMEDYREPACK INC.

Rising Pharma Holdings, Inc.

Shandong Xinhua Pharmaceutical Company Limited

Strides Pharma Science Limited

Taro Pharmaceuticals U.S.A. Inc.

Trigen Laboratories, LLC

VistaPharm, LLC

Westminster Pharmaceuticals, LLC

WINDER LABORATORIES, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 6 drug and cosmetic product listings (FDA).

•Phenobarbital
•Phenohytro
•Donnatal
•Phenobarbital Oral Solution
•Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide
•Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Phenobarbital Tablet
Shortage listed since October 31, 2025

See all current drug shortages

Chemical Identity

CAS50-06-6

PubChem CID4763

DTXSIDDTXSID5021122

FormulaC12H12N2O3

Mol. Weight232.23 g/mol

SMILESCCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2

Data Sources

PubChem · compound 4763Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

Phenobarbital (CAS 50-06-6) https://chemicalindependence.com/chemical/50-06-6/ PubChem: 4763. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4763 FDA National Drug Code directory: CAS 50-06-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 50-06-6. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293353 for CAS 50-06-6. Reporting year: 2024. https://usatrade.census.gov/