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Histidine

Drug ingredient

CAS 4998-57-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 4998-57-6
US productionNot reported
Import value, 2024$114M
Top sourceChina 26%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293329 · basket

These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy
13 FDA-registered drug labelers
Ajinomoto Health & Nutrition North America Inc.
B. Braun Medical Inc.
Baxter Healthcare Company
Baxter Healthcare Corporation
Energique, Inc.
Fresenius Kabi USA, LLC
ICU Medical Inc.
KYOWA HAKKO BIO CO., LTD.
Liddell Laboratories, Inc.
Nutritional Specialties, Inc.
Professional Complementary Health Formulas
Professional Compounding Centers of America
Shanghai Plumino Amino Acid Co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 16 drug and cosmetic product listings (FDA).

  • •Aminosyn-PF
  • •Plenamine
  • •Kabiven
  • •Clinimix
  • •Clinimix E
  • •Clinisol
  • •ProSol
  • •TrophAmine
Show all 16
  • •L-Histidine High 7410
  • •Aminosyn II
  • •Metabatone
  • •Vital Skin Hair Nails
  • •Travasol
  • •Perikabiven
  • •Metab
  • •Premasol - sulfite-free (Amino Acid)
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.37/gA2B Chem LLC
CountryUnited States
Pack$37.00 / 100 g
Purity97%
Vendors24 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

23 more vendors
VendorCountry$/gPackPurity
AA BLOCKSUnited States$0.41100 g97%
Combi-Blocks, Inc.United States$0.48500 g98%
Aaron Chemicals LLCHong Kong$0.50100 g98%
BLD Pharmatech Co., LimitedUnited States$0.51500 g95%
BLD Pharmatech GmbHGermany$0.51500 g95%
BLD Pharmatech Ltd.China$0.51500 g95%
Ambeed, Inc.United States$0.51500 g95%
Angene ChemicalChina → Hong Kong$0.53100 g98%
Acrotein ChemBio, Inc.United States$0.70250 g—
AstaTech, IncUnited States$0.79100 g97%
MedChemExpress MCESweden$0.87100 g99.9%
Fluorochem EUGermany$1.0625 g95%
AK Scientific SpecializedUnited States$1.28100 g95%
Fluorochem UKUnited Kingdom$1.2910 g95%
AK Scientific, Inc.United States$1.66100 g98%
Angene International LimitedUnited States$2.90100 g98%
Fulfilled by MolportLatvia$5.001 g—
Sigma-Aldrich (Rush Stock)Germany$10.59100 g99%
Sigma-AldrichGermany$10.59100 g99%
InterbioscreenHong Kong$34.0010 g95%
Otava, Ltd.Ukraine$2280.0050 mg95%
ChemDiv, Inc.United States$4070.00100 mg90%
AngeneChina → Hong Kong$4266.6730 mg98%

Chemical Identity

CAS4998-57-6
PubChem CIDNot recorded
DTXSIDDTXSID00901785
FormulaC6H9N3O2
Mol. Weight155.157 g/mol
SMILESNC(CC1=CN=CN1)C(O)=O

Data Sources

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Brief citations

Histidine (CAS 4998-57-6) https://chemicalindependence.com/chemical/4998-57-6/ EPA TSCA Inventory: CAS 4998-57-6. Retrieved 2026-10-04. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: CAS 4998-57-6. Retrieved 2026-10-04. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 4998-57-6. Reporting year: 2024. https://usatrade.census.gov/