Flag of the United StatesAmerican Chemical Independence

Trientine tetrahydrochloride

Drug ingredient

CAS 4961-40-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 4961-40-4
4 HCl
US productionNot reported
Import value, 2024$119M
Top sourceJapan 33%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292129 · basket

These shares come from HS customs code 292129, which covers 69 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
JP 33%JapanCA 14%CanadaNL 10%NetherlandsSE 7%SwedenDE 7%Germany
2 FDA-registered drug labelers
NURAY CHEMICALS PRIVATE LIMITED
Orphalan SA

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Cuvrior
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS4961-40-4
PubChem CID71434
DTXSIDDTXSID5063657
FormulaC6H22Cl4N4
Mol. Weight292.1 g/mol
SMILESC(CNCCNCCN)N.Cl.Cl.Cl.Cl

Data Sources

← Back to Dashboard← Back to Health

Brief citations

Trientine tetrahydrochloride (CAS 4961-40-4) https://chemicalindependence.com/chemical/4961-40-4/ PubChem: 71434. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/71434 EPA TSCA Inventory: CAS 4961-40-4. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292129 for CAS 4961-40-4. Reporting year: 2024. https://usatrade.census.gov/