isotretinoin

Drug ingredient

CAS 4759-48-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$87M

Top sourceSwitzerland 43%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293621 · basket

These shares come from HS customs code 293621, which covers 7 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CH 43%SwitzerlandCN 33%ChinaIT 13%ItalyIN 5%IndiaDK 4%Denmark

Israel
Japan
Taiwan
Canada
Australia
United Kingdom
Malaysia
Spain
Latvia
Georgia
Mexico

21 FDA-registered drug labelers

Actavis Pharma, Inc.

Amneal Pharmaceuticals NY LLC

Aurobindo Pharma Limited

BluePoint Laboratories

Catalent France Beinheim S.A

Chongqing Huapont Pharmaceutical Co Limited

Dr. Reddy's Laboratories Limited

HAS Healthcare Advanced Synthesis SA

HETERO DRUGS LIMITED

JG Pharma Inc.

Mayne Pharma

Mylan Pharmaceuticals Inc.

Olon S.p.A.

Siegfried PharmaChemikalien Minden GmbH

Sionc Pharmaceutical Private Limited

Sun Pharmaceutical Industries, Inc.

Swiss Caps AG

Teva Pharmaceuticals USA, Inc.

Upsher-Smith Laboratories, LLC

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

•Isotretinoin
•Absorica LD
•Zenatane
•Amnesteem
•Accutane
•Claravis
•Absorica

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1.98/gAaron Chemicals LLC

CountryHong Kong

Pack$990.00 / 500 g

Purity98%

Vendors4 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

3 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$2.20	100 g	98%
Fulfilled by Molport	Latvia	$50.00	100 mg	98%
Apexbio Technology LLC	United States	$66.00	5 g	98%

Chemical Identity

CAS4759-48-2

PubChem CID5282379

DTXSIDDTXSID4023177

FormulaC20H28O2

Mol. Weight300.4 g/mol

SMILESCC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

Data Sources

PubChem · compound 5282379Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

isotretinoin (CAS 4759-48-2) https://chemicalindependence.com/chemical/4759-48-2/ PubChem: 5282379. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5282379 EPA TSCA Inventory: CAS 4759-48-2. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293621 for CAS 4759-48-2. Reporting year: 2024. https://usatrade.census.gov/