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Naloxone

Drug ingredient

CAS 465-65-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 465-65-6
US productionNot reported
Import value, 2024$50M
Top sourceIndia 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293919 · basket

These shares come from HS customs code 293919, which covers 12 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IN 37%IndiaIT 16%ItalyGB 15%United KingdomDE 10%GermanyDK 10%Denmark
4 FDA-registered drug labelers
Bryant Ranch Prepack
Dr.Reddys Laboratories Inc
Lannett Company, Inc.
Veranova, L.P.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Buprenorphine and Naloxone
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS465-65-6
PubChem CID5284596
DTXSIDDTXSID8023349
FormulaC19H21NO4
Mol. Weight327.4 g/mol
SMILESC=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O

Data Sources

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Brief citations

Naloxone (CAS 465-65-6) https://chemicalindependence.com/chemical/465-65-6/ PubChem: 5284596. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5284596 FDA National Drug Code directory: CAS 465-65-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293919 for CAS 465-65-6. Reporting year: 2024. https://usatrade.census.gov/