Obeticholic acid

Drug ingredient

CAS 459789-99-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$154M

Top sourceItaly 60%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293729 · basket

These shares come from HS customs code 293729, which covers 57 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 60%ItalyES 14%SpainCN 11%ChinaDE 6%GermanyAT 2%Austria

Netherlands
Australia
Malaysia
Portugal
United Kingdom
Japan
Malta
Canada
Israel
Singapore
New Zealand
Poland
Ukraine
Belgium
Sweden

9 FDA-registered drug labelers

Biophore India Pharmaceuticals Private Limited

Curia Spain S.A.U.

Hetero Labs Limited

Industriale Chimica s.r.l.

MSN Life Sciences Private Limited

Optimus Drugs Private Limited

Pharmacia & Upjohn Company LLC

Piramal Healthcare UK Limited

Teva Czech Industries s.r.o

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Obeticholic Acid Tablet
Shortage listed since September 19, 2025

See all current drug shortages

Chemical Identity

CAS459789-99-2

PubChem CID447715

DTXSIDDTXSID20196671

FormulaC26H44O4

Mol. Weight420.6 g/mol

SMILESCCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O

Data Sources

PubChem · compound 447715Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Obeticholic acid (CAS 459789-99-2) https://chemicalindependence.com/chemical/459789-99-2/ PubChem: 447715. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/447715 FDA National Drug Code directory: CAS 459789-99-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 459789-99-2. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293729 for CAS 459789-99-2. Reporting year: 2024. https://usatrade.census.gov/