3,4-Dihydro-2-methoxy-2H-pyran

CAS 4454-05-1

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$3.5B

Import volumeZero

Top sourceIreland 57%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293299 · basket

EPA reports by year

2023: US production Confidential · Imports Zero
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 293299, which covers 229 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 57%IrelandNL 24%NetherlandsCH 8%SwitzerlandCN 5%ChinaIT 2%Italy

United Kingdom
Japan
Germany
Spain
Israel
Canada
Brazil
Vietnam
Ukraine
New Zealand
Belgium
Mexico
Singapore
Taiwan
South Korea
Sweden
South Africa
Egypt
Indonesia
Lithuania
Finland
Hungary
Czech Republic
Hong Kong
Malaysia
Slovakia
Australia
Russia
Jordan
Latvia
Argentina
Slovenia
Malta
Poland
Denmark
Austria

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Lanxess

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in All Other Basic Organic Chemical ManufacturingProcessing as a reactant

Vendor Pricing

$0.09/gAaron Chemicals LLC

CountryHong Kong

Pack$43.00 / 500 g

Purity98%

Vendors9 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

8 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.10	500 g	98%
A2B Chem LLC	United States	$0.14	500 g	99%
AA BLOCKS	United States	$0.17	500 g	98%
Ambeed, Inc.	United States	$0.31	100 g	99%
Combi-Blocks, Inc.	United States	$0.40	500 g	97%
AstaTech, Inc	United States	$25.60	25 g	95%
Angene International Limited	United States	$42.12	25 g	95%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS4454-05-1

PubChem CID91538

DTXSIDDTXSID9027570

FormulaC6H10O2

Mol. Weight114.14 g/mol

SMILESCOC1CCC=CO1

Data Sources

EPA CompTox (DSSTox) · DTXSID9027570Retrieved 2026-04-06
PubChem · compound 91538Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

3,4-Dihydro-2-methoxy-2H-pyran (CAS 4454-05-1) https://chemicalindependence.com/chemical/4454-05-1/ EPA CompTox (DSSTox): DTXSID9027570. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027570 PubChem: 91538. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/91538 EPA Chemical Data Reporting: 4454-05-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 4454-05-1. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 293299 for CAS 4454-05-1. Reporting year: 2024. https://usatrade.census.gov/