Metronidazole
Drug ingredientActive ShortageCAS 443-48-1
This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.
US productionNot reported
Import value, 2024$114M
Top sourceChina 26%
This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293329 · basket
These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy
- Australia
- Brazil
- Czech Republic
- Ireland
- Sweden
- Ukraine
- Poland
- United Arab Emirates
- Hungary
- Israel
- Netherlands
- Canada
- Saudi Arabia
- Greece
- Belgium
- Austria
- Latvia
- Singapore
- Denmark
78 FDA-registered drug labelers
A-S Medication Solutions
Alembic Labs LLC
Alembic Pharmaceuticals Inc.
Alembic Pharmaceuticals Limited
American Health Packaging
AMICI PHARMA INC
Amneal Pharmaceuticals Private Limited
Asclemed USA, Inc.
Aurobindo Pharma Limited
AvPAK
B. Braun Medical Inc.
Bausch Health US, LLC
Baxter Healthcare Corporation
BluePoint Laboratories
Bryant Ranch Prepack
Cadila Pharmaceuticals Limited
Cardinal Health 107, LLC
Chartwell RX, LLC
Civica, Inc.
Corden Pharma Bergamo S.p.A.
Cosette Pharmaceuticals, Inc.
Direct_Rx
Encube Ethicals, Inc.
Endo USA, Inc.
Exeltis USA, Inc.
Fougera Pharmaceuticals, LLC
Galderma Laboratories, L.P.
Gland Pharma Limited
GLENMARK PHARMACEUTICALS INC., USA
Golden State Medical Supply, Inc.
Guangdong Quadrant Ecological Technology Co., Ltd.
H2-Pharma, LLC
Henry Schein, Inc.
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
Hospira, Inc.
Ingenus Pharmaceuticals, LLC
Jiangsu Chenpai Bond Pharmaceutical Co.,Ltd.
Jiangxi He-Oumei Health Industry Co., Ltd.
Kalchem International inc
Kesin Pharma Corporation
LETCO MEDICAL, LLC
Major Pharmaceuticals
Mayne Pharma Inc.
Medisca Inc.
Method Pharmaceuticals LLC
Northstar Rx LLC
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
Oceanside Pharmaceuticals
Padagis Israel Pharmaceuticals Ltd
PD-Rx Pharmaceuticals, Inc.
Pfizer Laboratories Div Pfizer Inc
Pharmasource Meds, LLC
PharmPak, Inc.
Prasco Laboratories
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
Quality Care Products LLC
Redpharm Drug
Redpharm Drug, inc.
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Sagent Pharmaceuticals
Saptalis Pharmaceuticals LLC
Solaris Pharma Corporation
Sportpharm LLC
ST. MARY'S MEDICAL PARK PHARMACY
Sun Pharmaceutical Industries, Inc.
Taro Pharmaceuticals U.S.A., Inc.
Teva Pharmaceuticals USA, Inc.
Unichem Laboratories Limited, India
Unichem Pharmaceuticals (USA), Inc.
Upsher-smith Laboratories, LLC
Viona Pharmaceuticals Inc
WG Critical Care, LLC
Xenex Laboratories Inc
Zydus Lifesciences Limited
Why It Matters
Sectors
Health
Downstream Uses
Appears in 18 drug and cosmetic product listings (FDA).
- •Metronidazole
- •Pylera
- •Acnil
- •Nuvessa
- •metronidazole vaginal
- •Metronidazole Vaginal Gel, 0.75%
- •Bismuth Subcitrate Potassium, Metronidazole and Tetracycline Hydrochloride
- •Vandazole
Show all 18
- •MetroCream
- •Seacall Mouthwash
- •Likmez
- •Metronidazole Vaginal Gel
- •Bismuth subcitrate potassium, Metronidazole, Tetracycline hydrochloride
- •Flagyl
- •Firming antibacterial
- •Noritate
- •Relfy
- •Metrogel
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
Active Shortage
Shortage History
Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.
- Current shortage
Metronidazole Injection
Shortage listed since January 13, 2022
Manufacturer reports: 1 unavailable, 1 limited, 1 available
Vendor Pricing
$0.07/gAaron Chemicals LLC
CountryHong Kong
Pack$34.00 / 500 g
Purity98%
Vendors34 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
33 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Angene Chemical | China → Hong Kong | $0.08 | 500 g | 98% |
| Chemscene | United States | $0.10 | 500 g | — |
| AA BLOCKS | United States | $0.11 | 100 g | 95% |
| Fluorochem EU | Germany | $0.16 | 100 g | 98% |
| A2B Chem LLC | United States | $0.23 | 500 g | 95% |
| AK Scientific Specialized | United States | $0.25 | 1 kg | 95% |
| Combi-Blocks, Inc. | United States | $0.25 | 1 kg | 98% |
| Fluorochem UK | United Kingdom | $0.34 | 25 g | 98% |
| AK Scientific, Inc. | United States | $0.35 | 1 kg | 99% |
| Fulfilled by Molport | Latvia | $0.50 | 10 g | 98% |
| Angene International Limited | United States | $0.72 | 500 g | 98% |
| AstaTech, Inc | United States | $0.80 | 250 g | 97% |
| Cayman Europe | Estonia | $2.90 | 100 g | 98% |
| Sigma-Aldrich (Rush Stock) | Germany | $3.74 | 100 g | — |
| Sigma-Aldrich | Germany | $3.74 | 100 g | — |
| ALFA AESAR | Germany | $4.30 | 100 g | 99% |
| MedChemExpress MCE | Sweden | $7.01 | 100 g | 99.99% |
| Apexbio Technology LLC | United States | $8.80 | 10 g | 99.96% |
| MedKoo Biosciences, Inc | United States | $18.00 | 25 g | 98% |
| CliniSciences GmbH | Switzerland | $32.25 | 1 g | 99% |
| Molnova | China | $82.00 | 500 mg | 99% |
| TargetMol Chemicals | China → United States | $92.00 | 500 mg | 99.98% |
| Interbioscreen | Hong Kong | $129.00 | 10 g | 95% |
| Vitas M Chemical Limited | Hong Kong | $306.00 | 5 g | 90% |
| Labotest KG | Germany | $453.00 | 1000 mg | 90% |
| Otava, Ltd. | Ukraine | $2280.00 | 50 mg | 95% |
| Maybridge, Ltd. | United Kingdom | $2414.30 | 100 mg | 90% |
| Princeton BioMolecular Research (SC) | United States | $2900.00 | 100 mg | 90% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 98% |
| Key Organics Ltd. | United Kingdom | $6900.00 | 10 mg | 97% |
| ChemDiv, Inc. | United States | $7666.67 | 15 mg | 90% |
| Asinex | Netherlands | $9292.80 | 50 mg | 90% |
| TimTec, LLC | United States | $9333.33 | 30 mg | 90% |
Chemical Identity
CAS443-48-1
PubChem CID4173
DTXSIDDTXSID2020892
FormulaC6H9N3O3
Mol. Weight171.15 g/mol
SMILESCC1=NC=C(N1CCO)[N+](=O)[O-]
Data Sources
- PubChem · compound 4173Retrieved 2026-04-07
- FDA National Drug Code directoryRetrieved 2026-04-25
- FDA Drug ShortagesRetrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Metronidazole (CAS 443-48-1) https://chemicalindependence.com/chemical/443-48-1/ PubChem: 4173. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4173 FDA National Drug Code directory: CAS 443-48-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 443-48-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293329 for CAS 443-48-1. Reporting year: 2024. https://usatrade.census.gov/