Macitentan

Drug ingredient

CAS 441798-33-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

12 FDA-registered drug labelers

Actelion Pharmaceuticals US, Inc.

Aurobindo Pharma Limited

Excella GmbH & Co. KG

Honour Lab Limited

Lonza AG

MSN Life Sciences Private Limited

MYLAN LABORATORIES LIMITED

PENN PHARMACEUTICAL SERVICES LIMITED

TAPI Croatia Industries Ltd.

Viyash Life Sciences Private Limited

Zhejiang Ausun Pharmaceutical Co., Ltd.

Zhejiang Lepu Pharmaceutical Co., Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Opsynvi
•Opsumit

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$53.00/gCombi-Blocks, Inc.

CountryUnited States

Pack$265.00 / 5 g

Purity95%

Vendors16 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

15 more vendors

Vendor	Country	$/g	Pack	Purity
BLD Pharmatech GmbH	Germany	$55.20	5 g	98%
BLD Pharmatech Ltd.	China	$55.20	5 g	98%
BLD Pharmatech Co., Limited	United States	$60.80	5 g	98%
Ambeed, Inc.	United States	$60.80	5 g	98%
AstaTech, Inc	United States	$228.00	250 mg	95%
TargetMol Chemicals	China → United States	$356.00	500 mg	99.99%
MedKoo Biosciences, Inc	United States	$392.50	20 g	98%
Molnova	China	$534.00	500 mg	99%
AK Scientific Specialized	United States	$1550.00	100 mg	95%
Apexbio Technology LLC	United States	$1900.00	100 mg	99.53%
Cayman Europe	Estonia	$1908.76	250 mg	98%
MedChemExpress MCE	Sweden	$2057.00	100 mg	99.87%
TargetMol Chemicals EU	Austria	$3700.00	10 mg	99.99%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	97%
AK Scientific, Inc.	United States	$24690.00	100 mg	99%

Chemical Identity

CAS441798-33-0

PubChem CID16004692

DTXSIDDTXSID50196063

FormulaC19H20Br2N6O4S

Mol. Weight588.3 g/mol

SMILESCCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br

Data Sources

PubChem · compound 16004692Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Macitentan (CAS 441798-33-0) https://chemicalindependence.com/chemical/441798-33-0/ PubChem: 16004692. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/16004692 FDA National Drug Code directory: CAS 441798-33-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 441798-33-0. Reporting year: 2024. https://usatrade.census.gov/