d-alpha-Tocopheryl succinate

Drug ingredient

CAS 4345-03-3

α-tocopherol succinate, d-

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$466M

Top sourceChina 65%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293628 · basket

These shares come from HS customs code 293628, which covers 11 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 65%ChinaCH 15%SwitzerlandDE 6%GermanyIT 3%ItalyAR 3%Argentina

South Korea
Belgium
Netherlands
Singapore
Canada
Denmark
United Kingdom
Australia
Ecuador
Brazil

4 FDA-registered drug labelers

Exeltis USA, Inc.

Hillestad Pharmaceuticals USA

Method Pharmaceuticals, LLC

V2 Pharma LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

•Dialyvite 5000
•Dialyvite 3000
•Cobalefol
•Strovite One Caplets
•Multi-Vitamin Drops with Fluoride and Iron
•Dialyvite Supreme D
•Multi-Vitamin with Fluoride

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS4345-03-3

PubChem CID20353

DTXSIDDTXSID2026151

FormulaC33H54O5

Mol. Weight530.8 g/mol

SMILESCC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)O)C

Data Sources

PubChem · compound 20353Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

d-alpha-Tocopheryl succinate (CAS 4345-03-3) https://chemicalindependence.com/chemical/4345-03-3/ PubChem: 20353. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/20353 EPA TSCA Inventory: CAS 4345-03-3. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293628 for CAS 4345-03-3. Reporting year: 2024. https://usatrade.census.gov/