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Midodrine hydrochloride

Drug ingredient

CAS 43218-56-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 43218-56-0
1 HCl
US productionNot reported
Import value, 2024$872M
Top sourceSwitzerland 44%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292429 · basket

These shares come from HS customs code 292429, which covers 203 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CH 44%SwitzerlandCN 19%ChinaIN 12%IndiaJP 9%JapanIE 6%Ireland
41 FDA-registered drug labelers
Advagen Pharma Limited
Alembic Pharmaceuticals Inc.
Alembic Pharmaceuticals Limited
American Health Packaging
Apotex Corp
Apotex Inc.
Aurobindo Pharma Limited
Avet Pharmaceuticals Inc.
AvKARE
AvPAK
Bryant Ranch Prepack
Cardinal Health 107, LLC
Coupler LLC
Edmond Pharma S.R.L
Emcure Pharmaceuticals Limited
Endo USA, Inc.
First Nation Group, LLC
Golden State Medical Supply, Inc.
Industriale Chimica s.r.l.
Ipca Laboratories Limited
Lifestar Pharma LLC
Major Pharmaceuticals
Midodrine Hydrochloride
Mylan Institutional Inc.
Mylan Pharmaceuticals Inc.
NCS HealthCare of KY, LLC dba Vangard Labs
NorthStar Rx LLC
Novugen Pharma (USA) LLC
Optimus Drugs Private Limited
Par Active Technologies Private Limited
PD-Rx Pharmaceuticals, Inc.
Proficient Rx LP
Rising Pharma Holdings, Inc.
Safecor Health LLC
Sterling Pharma Solutions Limited
TruPharma, LLC
Umasuto, LLC
Upsher-Smith laboratories, LLC
Xiromed, LLC
Zydus Lifesciences Limited
Zydus Pharmaceuticals (USA) Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Midodrine Hydrochloride
FDA Shortage Status
No Shortage

Vendor Pricing

$389.40/gSigma-Aldrich (Rush Stock)
CountryGermany
Pack$389.40 / 1 g
PurityNot recorded
Vendors15 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

14 more vendors
VendorCountry$/gPackPurity
Sigma-AldrichGermany$389.401 g—
Labotest KGGermany$453.001000 mg90%
A2B Chem LLCUnited States$584.00250 mg98%
AA BLOCKSUnited States$648.00250 mg98%
Cayman EuropeEstonia$928.20250 mg95%
Aaron Chemicals LLCHong Kong$1220.00100 mg98%
Angene ChemicalChina → Hong Kong$1240.00100 mg98%
MedKoo Biosciences, IncUnited States$2240.00250 mg98%
MolnovaChina$2580.00100 mg99%
TargetMol ChemicalsChina → United States$2870.00100 mg99.99%
AstaTech, IncUnited States$5980.00100 mg95%
Key Organics Ltd.United Kingdom$6900.0010 mg97%
MedChemExpress MCESweden$7986.0025 mg99.9%
Angene International LimitedUnited States$13240.0025 mg98%

Chemical Identity

CAS43218-56-0
PubChem CID18340
DTXSIDDTXSID1047493
FormulaC12H19ClN2O4
Mol. Weight290.74 g/mol
SMILESCOC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O.Cl

Data Sources

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Brief citations

Midodrine hydrochloride (CAS 43218-56-0) https://chemicalindependence.com/chemical/43218-56-0/ PubChem: 18340. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/18340 FDA National Drug Code directory: CAS 43218-56-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 43218-56-0. Retrieved 2026-06-13. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 292429 for CAS 43218-56-0. Reporting year: 2024. https://usatrade.census.gov/