2,4-Di-tert-butylphenyl 3′,5′-di-tert-butyl-4′-hydroxybenzoate

CAS 4221-80-1

EPA’s 2023 records show zero U.S. production of this chemical.

US productionZero

Import value, 2024$122M

Import volumeCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Top sourceSouth Korea 39%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291829 · basket

EPA reports by year

2023: US production Zero · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291829, which covers 85 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

KR 39%South KoreaCN 26%ChinaTW 11%TaiwanJP 9%JapanSG 5%Singapore

United Kingdom
Germany
Malaysia
Mexico
Ireland
Ukraine
Slovakia
Hungary
Spain

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Songwon Industrial · KR South Korea

Songwon

Why It Matters

Sectors

Plastics & Rubber

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•UV stabilizer in Plastics Material and Resin Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.41/gCombi-Blocks, Inc.

CountryUnited States

Pack$205.00 / 500 g

Purity98%

Vendors8 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

7 more vendors

Vendor	Country	$/g	Pack	Purity
BLD Pharmatech Ltd.	China	$0.54	100 g	98%
Aaron Chemicals LLC	Hong Kong	$0.65	500 g	98%
Angene Chemical	China → Hong Kong	$0.70	500 g	98%
AstaTech (2 weeks)	United States	$1.76	100 g	95%
A2B Chem LLC	United States	$1.82	100 g	98%
AA BLOCKS	United States	$2.36	100 g	98%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS4221-80-1

PubChem CID77897

DTXSIDDTXSID5063364

FormulaC29H42O3

Mol. Weight438.6 g/mol

SMILESCC(C)(C)C1=CC(=C(C=C1)OC(=O)C2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C)C(C)(C)C

Data Sources

EPA CompTox (DSSTox) · DTXSID5063364Retrieved 2026-04-06
PubChem · compound 77897Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

2,4-Di-tert-butylphenyl 3′,5′-di-tert-butyl-4′-hydroxybenzoate (CAS 4221-80-1) https://chemicalindependence.com/chemical/4221-80-1/ EPA CompTox (DSSTox): DTXSID5063364. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5063364 PubChem: 77897. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/77897 EPA Chemical Data Reporting: 4221-80-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 4221-80-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291829 for CAS 4221-80-1. Reporting year: 2024. https://usatrade.census.gov/