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Clonidine hydrochloride

Drug ingredient

CAS 4205-91-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 4205-91-8
1 HCl
US productionNot reported
Import value, 2024$114M
Top sourceChina 26%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293329 · basket

These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy
54 FDA-registered drug labelers
A-S Medication Solutions
Actavis Pharma, Inc.
Ajanta Pharma USA Inc.
Alembic Pharmaceuticals Inc.
Alembic Pharmaceuticals Limited
American Health Packaging
Aphena Pharma Solutions - Tennessee, LLC
Asclemed USA, Inc.
Aurobindo Pharma Limited
AvPAK
Azurity Pharmaceuticals, Inc.
BluePoint Laboratories
Bond Pharmacy INC
Bryant Ranch Prepack
Cardinal Health 107, LLC
Coupler LLC
DirectRX
Enaltec Labs Pvt Ltd
Galenova Inc
HF Acquisition Co LLC, DBA HealthFirst
Hikma Pharmaceuticals USA Inc.
Ingenus Pharmaceuticals, LLC
LETCO MEDICAL, LLC
Lupin Pharmaceuticals, Inc.
Major Pharmaceuticals
Medisca Inc.
Method Pharmaceuticals, LLC
Mylan Institutional LLC
NCS HealthCare of KY, LLC dba Vangard Labs
NextWave Pharmaceuticals, Inc
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
PCAS FINLAND OY
PD-Rx Pharmaceuticals, Inc.
Pharma Source Direct, Inc.
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
Redpharm Drug
REMEDYREPACK INC.
Societa Italiana Medicinali Scandicci S.I.M.S., SrL
Solco Healthcare LLC
Somerset Therapeutics, LLC
Spectrum Laboratory Products, Inc.
ST. MARY'S MEDICAL PARK PHARMACY
TruPharma, LLC
Unichem Laboratories Limited, India
Unichem Pharmaceuticals (USA), Inc.
VERITYRX, LLC
Xenex Laboratories Inc
XGen Pharmaceuticals DJB, Inc.
Xiamen LP Pharmaceutical Co., Ltd.
YUNG ZIP CHEMICAL INDUSTRIAL CO., LTD.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 6 drug and cosmetic product listings (FDA).

  • •Clonidine Hydrochloride
  • •Clonidine HCI
  • •Clonidine
  • •Duraclon
  • •Onyda XR
  • •Javadin
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS4205-91-8
PubChem CID20179
DTXSIDDTXSID8044670
FormulaC9H10Cl3N3
Mol. Weight266.6 g/mol
SMILESC1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl

Data Sources

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Brief citations

Clonidine hydrochloride (CAS 4205-91-8) https://chemicalindependence.com/chemical/4205-91-8/ PubChem: 20179. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/20179 FDA National Drug Code directory: CAS 4205-91-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 4205-91-8. Reporting year: 2024. https://usatrade.census.gov/