Trifluoroacetic anhydride

CAS 407-25-0

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$384M

Top sourceMalaysia 21%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291590 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291590, which covers 588 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

MY 21%MalaysiaDE 13%GermanyNL 13%NetherlandsMX 10%MexicoIT 8%Italy

Singapore
Austria
United Kingdom
Philippines
Canada
Hungary
Turkey
Ukraine
Israel
Denmark
Czech Republic
Slovakia
Norway
Poland
Hong Kong
South Africa
Russia

Why It Matters

Sectors

HealthMetals & Mining

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 2 sectors as 1 functional role.

•Intermediate in Miscellaneous ManufacturingProcessing as a reactant
•Intermediate in Pharmaceutical and Medicine ManufacturingProcessing as a reactant

Vendor Pricing

$0.10/gApollo Scientific US

CountryUnited Kingdom

Pack$96.00 / 1 kg

Purity99%

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
Fluorochem UK	United Kingdom	$0.10	1 kg	99%
Sigma-Aldrich (Rush Stock)	Germany	$0.34	500 g	99%
Sigma-Aldrich	Germany	$0.34	500 g	99%
A2B Chem LLC	United States	$1.48	250 g	98%
AK Scientific, Inc.	United States	$1.52	100 g	99%
AA BLOCKS	United States	$1.66	250 g	98%
AstaTech, Inc	United States	$2.79	100 g	95%
Labotest KG	Germany	$453.00	1000 mg	90%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%

Chemical Identity

CAS407-25-0

PubChem CID9845

DTXSIDDTXSID90861920

FormulaC4F6O3

Mol. Weight210.03 g/mol

SMILESC(=O)(C(F)(F)F)OC(=O)C(F)(F)F

Data Sources

EPA CompTox (DSSTox) · DTXSID90861920Retrieved 2026-04-06
PubChem · compound 9845Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Trifluoroacetic anhydride (CAS 407-25-0) https://chemicalindependence.com/chemical/407-25-0/ EPA CompTox (DSSTox): DTXSID90861920. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID90861920 PubChem: 9845. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/9845 EPA Chemical Data Reporting: 407-25-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 407-25-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291590 for CAS 407-25-0. Reporting year: 2024. https://usatrade.census.gov/