nickel carbonate hydroxide tetrahydrate

Drug ingredient

CAS 39430-27-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 39430-27-8 — 4 H₂O · 4 OH⁻ · 3 Ni²⁺

US productionNot reported

Import value, 2024$116M

Top sourceAustralia 23%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 283699 · basket

These shares come from HS customs code 283699, which covers 26 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

AU 23%AustraliaDE 17%GermanyCN 15%ChinaPH 13%PhilippinesFI 9%Finland

South Korea
Malaysia
Turkey
Sweden
Czech Republic
Peru
Mexico
Spain
Switzerland
Belgium

3 FDA-registered drug labelers

Hahnemann Laboratories, INC.

Natural Creations, Inc.

Zorex International

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Niccolum Carbonicum
•H.M.D.
•Alumizen

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS39430-27-8

PubChem CID76955832

DTXSIDDTXSID90872950

FormulaCH12Ni3O11

Mol. Weight376.18 g/mol

SMILESC(=O)([O-])[O-].O.O.O.O.[OH-].[OH-].[OH-].[OH-].[Ni+2].[Ni+2].[Ni+2]

Data Sources

PubChem · compound 76955832Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

nickel carbonate hydroxide tetrahydrate (CAS 39430-27-8) https://chemicalindependence.com/chemical/39430-27-8/ PubChem: 76955832. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/76955832 FDA National Drug Code directory: CAS 39430-27-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 283699 for CAS 39430-27-8. Reporting year: 2024. https://usatrade.census.gov/