carbidopa hydrate

Drug ingredient

CAS 38821-49-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 38821-49-7 — 1 H₂O

US productionNot reported

Import value, 2024$191M

Top sourceSwitzerland 35%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292800 · basket

These shares come from HS customs code 292800, which covers 112 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CH 35%SwitzerlandIT 28%ItalyCN 12%ChinaIN 6%IndiaJP 6%Japan

Canada
Spain
Mexico
Netherlands
Poland
Malta
Norway
Ukraine
Belgium
Israel
Czech Republic
Austria
Indonesia
United Arab Emirates
Brazil
Lithuania

7 FDA-registered drug labelers

AbbVie Inc.

Amneal Pharmaceuticals LLC

Avion Pharmaceuticals, LLC

Cardinal Health 107, LLC

LETCO MEDICAL, LLC

Safecor Health, LLC

Teva Pharmaceuticals USA, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

•Rytary
•Carbidopa and levodopa
•Crexont
•Dhivy
•Duopa

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS38821-49-7

PubChem CID38101

DTXSIDDTXSID50904589

FormulaC10H16N2O5

Mol. Weight244.24 g/mol

SMILESCC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN.O

Data Sources

PubChem · compound 38101Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

carbidopa hydrate (CAS 38821-49-7) https://chemicalindependence.com/chemical/38821-49-7/ PubChem: 38101. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/38101 FDA National Drug Code directory: CAS 38821-49-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292800 for CAS 38821-49-7. Reporting year: 2024. https://usatrade.census.gov/