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Bupivacaine

Drug ingredientActive Shortage

CAS 38396-39-3

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 38396-39-3
US productionNot reported
Import value, 2024$1.3B
Top sourceChina 32%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293339 · basket

These shares come from HS customs code 293339, which covers 397 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 32%ChinaIN 15%IndiaDE 10%GermanyBE 9%BelgiumCH 8%Switzerland
10 FDA-registered drug labelers
Bond Pharmacy INC
Cambrex Karlskoga AB
DISHMAN CARBOGEN AMCIS LIMITED
Heron Therapeutics, Inc.
Jiangsu Hengrui Pharmaceuticals Co., Ltd.
MSN Life Sciences Private Limited
Nortec Quimica SA
Pacira Pharmaceuticals, Inc.
Patheon UK Limited
Siegfried Evionnaz SA

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Zynrelef
  • •Exparel
  • •Bupivacaine
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Bupivacaine Hydrochloride Injection

    Shortage listed since February 20, 2018

    Manufacturer reports: 1 unavailable, 1 available

  • Current shortage

    Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection

    Shortage listed since February 20, 2018

    Manufacturer reports: 1 unavailable, 1 available

See all current drug shortages

Vendor Pricing

$5.90/gAaron Chemicals LLC
CountryHong Kong
Pack$590.00 / 100 g
Purity98%
Vendors17 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

16 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$5.95100 g98%
A2B Chem LLCUnited States$7.86100 g98%
AK Scientific SpecializedUnited States$9.1225 g95%
AA BLOCKSUnited States$10.31100 g98%
AK Scientific, Inc.United States$12.2425 g98%
Cayman EuropeEstonia$13.5225 g98%
Biopharma PEG Scientific Inc.United States$31.6025 g98%
AstaTech, IncUnited States$40.005 g95%
MedKoo Biosciences, IncUnited States$50.0025 g98%
InterbioscreenHong Kong$129.0010 g95%
MedChemExpress MCESweden$225.06500 mg99.96%
TargetMol ChemicalsChina → United States$660.0050 mg99.99%
HTS Biochemie InnovationenGermany$1790.00100 mg95%
Key Organics Ltd.United Kingdom$2740.0050 mg90%
Life Chemicals Inc.Ukraine → Canada$4200.0050 mg90%
AngeneChina → Hong Kong$4266.6730 mg98%

Chemical Identity

CAS38396-39-3
PubChem CID2474
DTXSIDDTXSID2022703
FormulaC18H28N2O
Mol. Weight288.4 g/mol
SMILESCCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C

Data Sources

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Brief citations

Bupivacaine (CAS 38396-39-3) https://chemicalindependence.com/chemical/38396-39-3/ PubChem: 2474. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/2474 EPA TSCA Inventory: CAS 38396-39-3. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 38396-39-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293339 for CAS 38396-39-3. Reporting year: 2024. https://usatrade.census.gov/