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Diphenoxylate hydrochloride

Drug ingredient

CAS 3810-80-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 3810-80-8
1 HCl
US productionNot reported
Import value, 2024$2M
Top sourceSwitzerland 86%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293333 · basket

These shares come from HS customs code 293333, which covers 11 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CH 86%SwitzerlandCN 11%ChinaIT 1%ItalyUA 1%Ukraine
22 FDA-registered drug labelers
A-S Medication Solutions
American Health Packaging
ANI Pharmaceuticals, Inc.
Aphena Pharma Solutions - Tennessee, LLC
Bryant Ranch Prepack
Chartwell RX, LLC
Direct Rx
Hikma Pharmaceuticals USA Inc.
KALINTIS HEALTHCARE PRIVATE LIMITED
Leading Pharma, LLC
Mylan Pharmaceuticals Inc.
NuCare Pharmaceuticals,Inc.
PD-Rx Pharmaceuticals, Inc.
Pfizer Laboratories Div Pfizer Inc
Preferred Pharmaceuticals Inc.
Proficient Rx LP
Redpharm Drug Inc.
REMEDYREPACK INC.
SpecGx LLC
Unichem Pharmaceuticals (USA), Inc.
Veranova, L.P.
Winder Laboratories LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Diphenoxylate Hydrochloride and Atropine Sulfate
  • •Lomotil
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS3810-80-8
PubChem CID6432394
DTXSIDDTXSID3047843
FormulaC30H33ClN2O2
Mol. Weight489 g/mol
SMILESCCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4.Cl

Data Sources

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Brief citations

Diphenoxylate hydrochloride (CAS 3810-80-8) https://chemicalindependence.com/chemical/3810-80-8/ PubChem: 6432394. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6432394 FDA National Drug Code directory: CAS 3810-80-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293333 for CAS 3810-80-8. Reporting year: 2024. https://usatrade.census.gov/