Citrulline

Drug ingredient

CAS 372-75-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$371M

Top sourceChina 27%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292419 · basket

These shares come from HS customs code 292419, which covers 211 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 27%ChinaIN 18%IndiaDE 14%GermanyIT 10%ItalyGB 6%United Kingdom

Hungary
Austria
Spain
Egypt
Canada
Sweden
Ukraine
Denmark
Israel
Lithuania
Greece
Ireland
Taiwan
Uruguay
Turkey
Australia
Singapore
Latvia
Colombia

4 FDA-registered drug labelers

Deseret Biologicals, Inc.

Qingdao Biopeptek Co., Ltd.

Qingdao Qinzeyuan Biotechnology Co., Ltd

ZHEJIANG TOP MEDICINE CO., LTD

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Vascuflow

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1.94/gAaron Chemicals LLC

CountryHong Kong

Pack$194.00 / 100 g

Purity98%

Vendors23 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

22 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$2.23	100 g	98%
Combi-Blocks, Inc.	United States	$4.70	100 g	97%
A2B Chem LLC	United States	$4.72	25 g	97%
BLD Pharmatech GmbH	Germany	$5.25	100 g	97%
BLD Pharmatech Ltd.	China	$5.25	100 g	97%
AA BLOCKS	United States	$5.28	25 g	97%
BLD Pharmatech Co., Limited	United States	$5.29	100 g	97%
Ambeed, Inc.	United States	$5.29	100 g	97%
Interbioscreen	Hong Kong	$17.00	10 g	95%
MedKoo Biosciences, Inc	United States	$22.00	25 g	98%
AK Scientific, Inc.	United States	$26.00	1 g	97%
Angene International Limited	United States	$76.00	1 g	97%
TargetMol Chemicals EU	Austria	$80.00	500 mg	99.99%
AstaTech (2 weeks)	United States	$80.00	1 g	95%
MedChemExpress MCE	Sweden	$125.84	500 mg	99.88%
Labotest KG	Germany	$217.80	5000 mg	90%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%
Angene	China → Hong Kong	$4266.67	30 mg	98%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	97%
Vitas M Chemical Limited	Hong Kong	$9000.00	10 mg	90%
Princeton BioMolecular Research (SC)	United States	$10500.00	10 mg	90%

Chemical Identity

CAS372-75-8

PubChem CID9750

DTXSIDDTXSID80883373

FormulaC6H13N3O3

Mol. Weight175.19 g/mol

SMILESC(CC(C(=O)O)N)CNC(=O)N

Data Sources

PubChem · compound 9750Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Citrulline (CAS 372-75-8) https://chemicalindependence.com/chemical/372-75-8/ PubChem: 9750. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9750 EPA TSCA Inventory: CAS 372-75-8. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292419 for CAS 372-75-8. Reporting year: 2024. https://usatrade.census.gov/