pemetrexed disodium hemipentahydrate

Drug ingredient

CAS 357166-30-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 357166-30-4 — 5 H₂O · 4 Na⁺

US productionNot reported

Top sourceNo public record

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Where It Comes From

EPA and Census publish no US supply data for this chemical.

15 FDA-registered drug labelers

Accord Healthcare Inc.

Amneal Pharmaceuticals LLC

BluePoint Laboratories

Camber Pharmaceuticals, Inc.

Emcure Pharmaceuticals Limited

Eugia US LLC

Hetero Labs Limited

Meitheal Pharmaceuticals Inc.

MSN Laboratories Private Limited

NorthStar RxLLC

Qilu Pharmaceutical Co., Ltd.

Sagent Pharmaceuticals

ScinoPharm Taiwan Ltd.

Shilpa Medicare Limited

Solco Healthcare US, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Pemetrexed
•Pemrydi RTU

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$10.92/gAaron Chemicals LLC

CountryHong Kong

Pack$273.00 / 25 g

Purity99%

Vendors6 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

5 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$12.52	25 g	99%
A2B Chem LLC	United States	$12.60	5 g	99%
AA BLOCKS	United States	$13.60	25 g	99%
Angene International Limited	United States	$20.20	25 g	95%
Angene	China → Hong Kong	$4266.67	30 mg	99%

Chemical Identity

CAS357166-30-4

PubChem CID135564527

DTXSIDDTXSID10189239

FormulaC40H48N10Na4O17

Mol. Weight1032.8 g/mol

SMILESC1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]

Data Sources

PubChem · compound 135564527Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07

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Brief citations

pemetrexed disodium hemipentahydrate (CAS 357166-30-4) https://chemicalindependence.com/chemical/357166-30-4/ PubChem: 135564527. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135564527 FDA National Drug Code directory: CAS 357166-30-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/