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Naloxone hydrochloride

Drug ingredient

CAS 357-08-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 357-08-4
1 HCl
US productionNot reported
Import value, 2024$50M
Top sourceIndia 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293919 · basket

These shares come from HS customs code 293919, which covers 12 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IN 37%IndiaIT 16%ItalyGB 15%United KingdomDE 10%GermanyDK 10%Denmark
59 FDA-registered drug labelers
A-S Medication Solutions
Actavis Pharma, Inc.
Advanced Rx of Tennessee, LLC
AMERISOURCE BERGEN
Amneal Pharmaceuticals NY LLC
Asclemed USA, Inc.
Aspen Oss B.V.
Aveva Drug Delivery Systems Inc.
AvKARE
Baxter Healthcare Corporation
BluePoint Laboratories
BPI Labs LLC
Bryant Ranch Prepack
Civica, Inc.
CVS Pharmacy, Inc
Dr. Reddy's Laboratories, Inc.
Emergent Devices Inc.
Eugia US LLC
FRANCOPIA
Fresenius Kabi USA, LLC
Harm Reduction Therapeutics, Inc.
Henry Schein, Inc
HF Acquisition Co LLC, DBA HealthFirst
Hikma Pharmaceuticals USA Inc.
Hikma Specialty USA Inc.
Hospira, Inc.
INDIVIOR INC.
INGENUS PHARMACEUTICALS, LLC
International Medication Systems, Limited
International Medication Systems, Ltd.
Kaleo, Inc.
Lifestar Pharma LLC
Lupin Pharmaceuticals,Inc.
Medical Purchasing Solutions, LLC
Meitheal Pharmaceuticals Inc.
Mylan Institutional LLC
NorthStar RxLLC
Orexo US, Inc.
Padagis Israel Pharmaceuticals Ltd
PAI Holdings, LLC dba Pharmaceutical Associates, Inc. and dba PAI Pharma
Par Health USA, LLC
Proficient Rx LP
ProPharma Distribution
Redpharm Drug
REMEDYREPACK INC.
Saneca Pharmaceuticals a.s.
Sanofi Winthrop Industrie
Scienture LLC
Siegfried AG
Sina Health Inc
Somerset Therapeutics, LLC
SpecGx LLC
Sportpharm, Inc. dba Sportpharm
Strategic Sourcing Services LLC
Sun Pharmaceutical Industries, Inc.
Teva Pharmaceuticals USA, Inc.
Teva Pharmaceuticals, Inc.
Walgreen Co.
ZMI Pharma Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 17 drug and cosmetic product listings (FDA).

  • •Naloxone Hydrochloride
  • •Buprenorphine and Naloxone
  • •Narcan
  • •Zubsolv
  • •Suboxone
  • •RiVive
  • •Zimhi
  • •Kloxxado
Show all 17
  • •Narcan Naloxone HCI
  • •Naloxone HCI
  • •Rezenopy
  • •Naloxone HCl
  • •Pentazocine and naloxone
  • •Pentazocine Hydrochloride AND Naloxone Hydrochloride
  • •Narcan Naloxone HCL
  • •Naloxone Hydrochloride Injection, USP, Auto-Injector
  • •Rextovy
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS357-08-4
PubChem CID5464092
DTXSIDDTXSID70957097
FormulaC19H22ClNO4
Mol. Weight363.8 g/mol
SMILESC=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl

Data Sources

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Brief citations

Naloxone hydrochloride (CAS 357-08-4) https://chemicalindependence.com/chemical/357-08-4/ PubChem: 5464092. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5464092 FDA National Drug Code directory: CAS 357-08-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293919 for CAS 357-08-4. Reporting year: 2024. https://usatrade.census.gov/